乌头属二萜生物碱的药理学与毒理学作用及挑战

doi:10.19803/j.1672-8629.20250195

中国药物警戒 ›› 2025, Vol. 22 ›› Issue (6): 601-607.
DOI: 10.19803/j.1672-8629.20250195

乌头属二萜生物碱的药理学与毒理学作用及挑战

孙英浩¹, 臧双耀^2△, 于文慧¹, 郭帅¹, 李婷婷¹, 张毅³, 张廷剑^1#, 孟繁浩^1*

¹中国医科大学药学院,小分子靶向抗肿瘤药物研究与开发重点实验室,辽宁沈阳 110122;
²中国医科大学附属第一医院,辽宁沈阳 110801;
³安徽新华学院药学院,安徽合肥 230088

收稿日期:2025-04-01 发布日期:2025-06-18
通讯作者: ^*孟繁浩,男,二级教授·博导,药物研究与开发。E-mail: fhmeng@cmu.edu.cn;^#为共同通信作者。孟繁浩,药学博士,二级教授,博士研究生导师。国务院政府特殊津贴专家、辽宁省特聘教授。中国药理学会抗炎免疫药理学专业委员会常委、辽宁省药学会药物化学专业委员会副主任委员、辽宁省生物技术协会理事、辽宁省突发公共卫生事件专家咨询委员会专家。主编《药物化学》《药物设计学》等高等医药院校统编教材16部。已发表学术论文200余篇,发明专利35项,计算机软件著作权登记证书3项,新药证书10项。获得辽宁省科技进步一等奖/二等奖、辽宁省普通高等教育教学一等奖、辽宁省自然科学学术成果二等奖等多项成果。《中国药物警戒》等期刊编委。
作者简介:孙英浩,男,硕士研究生,药物作用机制研究。^△为并列第一作者。
基金资助:
国家自然科学基金资助项目（82474134、81573687）

Effects and Challenges of Pharmacology and Toxicology of Aconitum Diterpenoid Alkaloids

SUN Yinghao¹, ZANG Shuangyao^2△, YU Wenhui¹, GUO Shuai¹, LI Tingting¹, ZHANG Yi³, ZHANG Tingjian^1#, MENG Fanhao^1*

¹School of Pharmacy, Key Laboratory of Research and Development of Small Molecule Targeted Antitumor Drugs, China Medical University, Shenyang Liaoning 110122, China;
²The First Hospital of China Medical University, Shenyang Liaoning 110801, China;
³School of Pharmacy, Anhui Xinhua University, Hefei Anhui 230088, China

Received:2025-04-01 Published:2025-06-18

摘要/Abstract

摘要： 目的总结乌头属二萜生物碱的药理学作用、毒理学机制及最新研究进展,为其安全应用与开发提供参考。方法通过文献调研与数据整合,分析乌头二萜生物碱的分子作用机制、药效学特性及毒性相关问题。结果乌头二萜生物碱具有显著的心血管保护、神经调节、抗炎、抗癌及抗菌活性,其作用机制涉及PI3K/Akt、MAPK、NF-κB等信号通路的调控,需关注其心脏毒性（线粒体凋亡途径）和肝毒性（PI3K/Akt/mTOR通路介导的自噬）。结论目前关于乌头二萜生物碱构效关系的研究报道较少,现有文献大多通过药效实验论证药理作用和毒性反应,乌头二萜生物碱具有广阔的临床应用潜力,但毒性问题亟待解决。

关键词: 乌头, 二萜生物碱, 心血管保护, 神经调节, 心脏毒性, 肝毒性, 药理学, 毒理学

Abstract: Objective To summarize the pharmacological effects, toxicological mechanisms, and research progress related to Aconitum diterpenoid alkaloids so as to provide a reference for safe applications and development. Methods Based on a literature review and data integration, the molecular mechanisms, pharmacology, and toxicity of Aconitum diterpenoid alkaloids were analyzed. Results Aconitum diterpenoid alkaloids exhibited significant cardiovascular protective, neuroregulatory, anti-inflammatory, anticancer, and antimicrobial properties. The mechanisms involved the regulation of signaling pathways such as PI3K/Akt, MAPK, and NF-κB. However, their cardiotoxicity (through mitochondrial apoptosis pathways) and hepatotoxicity (mediated by PI3K/Akt/mTOR pathway-driven autophagy) deserved more attention. Conclusion There are relatively few research reports on the structure-activity relationship of Aconitum diterpenoid alkaloids. Most of the literature currently available is concerned with the pharmacological effects and toxic reactions studied through pharmacological experiments. Aconitum diterpenoid alkaloids promise good applications, but the toxicity remains an urgent issue.

Key words: Aconitum, Diterpenoid Alkaloids, Cardiovascular Protection, Neuroregulatory, Cardiotoxicity, Hepatotoxicity, Pharmacology, Toxicology

中图分类号:

R961
R994.11

孙英浩, 臧双耀, 于文慧, 郭帅, 李婷婷, 张毅, 张廷剑, 孟繁浩. 乌头属二萜生物碱的药理学与毒理学作用及挑战[J]. 中国药物警戒, 2025, 22(6): 601-607.

SUN Yinghao, ZANG Shuangyao, YU Wenhui, GUO Shuai, LI Tingting, ZHANG Yi, ZHANG Tingjian, MENG Fanhao. Effects and Challenges of Pharmacology and Toxicology of Aconitum Diterpenoid Alkaloids[J]. Chinese Journal of Pharmacovigilance, 2025, 22(6): 601-607.

导出引用管理器 EndNote|Ris|BibTeX

链接本文: https://zgywjj.magtechjournal.com/CN/10.19803/j.1672-8629.20250195

https://zgywjj.magtechjournal.com/CN/Y2025/V22/I6/601

参考文献

[1] HONG LL, DING YF, ZHANG W, et al.Chemical and Biological Diversity of New Natural Products from Marine Sponges: a Review (2009-2018)[J]. Marine Life Science & Technology, 2022, 4(3): 356-372.
[2] ZHANG L, MIAO X, LI Y, et al.Traditional Processing, Uses, Phytochemistry, Pharmacology and Toxicology of Aconitum Sinom-ontanum Nakai: a Comprehensive Review[J]. Journal of Ethnophar-macology, 2022, 293: 115317.
[3] WU CT, YUE RS, HE MM, et al.Application Rule Analysis of Synopsis of Golden Chamber Wutou Decoction Based on Data Mining of Medical Case[J]. Chinese Journal of Basic Medicine in Traditional Chinese Medicine(中国中医基础医学杂志), 2022, 28(4): 614-618.
[4] LI CY, ZHOU Z, XU T, et al.Aconitum Pendulum and Aconitum Flavum: a Narrative Review on Traditional Uses, Phytochemistry, Bioactivities and Processing Methods[J]. Journal of Ethnopharm-acology, 2022, 292: 115216.
[5] WANG Y, LIN ZJ, JIANG ZX, et al.Early Warning of Aconitum Herbs in Breast Cancer Therapy by Bibliometric and Bioinformatics[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2021, 18(7): 655-662.
[6] LIANG X, SU W, ZHANG W, et al.An Overview of the Research Progress on Aconitum carmichaelii Debx.: Active Compounds, Pharmacology, Toxicity, Detoxification, and Applications[J]. Journal of Ethnopharmacology, 2025, 337: 118832.
[7] LI L, ZHANG L, LIAO T, et al.Advances on Pharmacology and Toxicology of Aconitine[J]. Fundamental & Clinical Pharmacology, 2022, 36(4): 601-611.
[8] HE YN, ZHANG DK, LIN JZ, et al.Cardiac Function Evaluation for a Novel One-Step Detoxification Product of Aconiti Lateralis Radix Praeparata[J]. Chinese Medical Journal, 2018, 13: 62.
[9] XIE GH, MA ZC, MEI Y, et al.Evaluation of Pharmacokinetics of Aconiti Lateralis Radix of Shenfu Prescription in Rats with Heart Failure[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2021, 18(7): 632-636.
[10] ZHANG J, LI D, ZHONG D, et al.Processed lateral root of Aconitum carmichaelii Debx.: a Review of Cardiotonic Effects and Cardiotoxicity on Molecular Mechanisms[J]. Frontiers in Pharmacology, 2022, 13: 1026219.
[11] WANG L, DENG H, WANG T, et al.Investigation into the Protective Effects of Hypaconitine and Glycyrrhetinic Acid Against Chronic Heart Failure of the Rats[J]. BMC Complementary Medicine and Therapies, 2022, 22(1): 160.
[12] WEN J, LI L, OU D, et al.Higenamine Protects Against Doxorubicin-Induced Heart Failure by Attenuating Ferroptosis via Modulating the Nrf2/GPX4 Signaling Pathway[J]. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, 2025, 141: 156670.
[13] WANG MY, LIANG JW, OLOUNFEH KM, et al.A Comprehensive in Silicon Method to Study the QSTR of the Aconitine Alkaloids for Designing the Novel Drugs[J]. Molecules, 2018, 23(9): 2385.
[14] ZENG W, YANG F, SHEN WL, et al.Interactions between Central Nervous System and Peripheral Metabolic Organs[J]. Science China. Life Sciences, 2022, 65(10): 1929-1958.
[15] ZHU X, LIU S, CAO Z, et al.Higenamine Mitigates Interleukin-1β-Induced Human Nucleus Pulposus Cell Apoptosis by ROS-Mediated PI3K/Akt Signaling[J]. Molecular and Cellular Biochemistry, 2021, 476: 3889-3897.
[16] LI D, YANG K, LI J, et al.Single-Cell Sequencing Reveals Glial Cell Involvement in Development of Neuropathic Pain via Myelin Sheath Lesion Formation in the Spinal Cord[J]. Journal of Neuroinflamm-ation, 2024, 21(1): 213.
[17] ZHU XZ, WANG JQ, WU YH.MG53 Ameliorates Nerve Injury Induced Neuropathic Pain through the Regulation of Nrf2/HO-1 Signaling in Rats[J]. Behavioural Brain Research, 2023, 449: 114489.
[18] WU YZ, SHAO S, GUO QL, et al.Aconicatisulfonines A and B, Analgesic Zwitterionic C₂₀-Diterpenoid Alkaloids with a Rearranged Atisane Skeleton from Aconitum carmichaelii[J]. Organic Letters, 2019, 21(17): 6850-6854.
[19] TANIMURA Y, YOSHIDA M, ISHIUVHI K, et al.Neoline is the Active Ingredient of Processed Aconite Root Against Murine Peripheral Neuropathic Pain Model, and Its Pharmacokinetics in Rats[J]. Journal of Ethnopharmacology, 2019, 241: 111859.
[20] SHAO S, XIA H, HU M, et al.Isotalatizidine, a C₁₉-Diterpenoid Alkaloid, Attenuates Chronic Neuropathic Pain through Stimulating ERK/CREB Signaling Pathway-Mediated Microglial Dynorphin A Expression[J]. Journal of Neuroinflammation, 2020, 17(1): 13.
[21] SUN ML, AO JP, WANG YR, et al.Lappaconitine, a C₁₈-Diterpenoid Alkaloid, Exhibits Antihypersensitivity in Chronic Pain through Stimulation of Spinal Dynorphin A Expression[J]. Psychopharmacology (Berl), 2018, 235(9): 2559-2571.
[22] XIE MX, YANG J, PANG RP, et al.Bulleyaconitine A Attenuates Hyperexcitability of Dorsal Root Ganglion Neurons Induced by Spared Nerve Injury: the Role of Preferably Blocking Nav1.7 and Nav1.3 Channels[J]. Molecular Pain, 2018, 14: 1744806918778491.
[23] AHMAD H, AHMAD S, SHAH SAA, et al.Antioxidant and Anticholinesterase Potential of Diterpenoid Alkaloids from Aconitum heterophyllum[J]. Bioorganic & Medicinal Chemistry, 2017, 25(13): 3368-3376.
[24] SALEHI A, GHANADIAN M, ZOLFAGHARI B, et al.Neurophar-macological Potential of Diterpenoid Alkaloids[J]. Pharmaceuticals (Basel, Switzerland), 2023, 16(5): 747.
[25] BALI ZK, BRUSZT N, KOSZEGI Z, et al.Aconitum Alkaloid Songorine Exerts Potent Gamma-Aminobutyric Acid-A Receptor Agonist Action in vivo and Effectively Decreases Anxiety without Adverse Sedative or Psychomotor Effects in the Rat[J]. Pharmaceutics, 2022, 14(10): 2067.
[26] NESTEROVA YV, VSYAKIKH OV, KUL'PIN PV, et al. Comparative Study of the Anxiolytic Activity of Songorine in Elevated Plus Maze Test and by Recording Ultrasonic Vocalizations[J]. Bulletin of Experimental Biology and Medicine, 2024, 177(5): 648-652.
[27] ZANG X, CHEN S, ZHU J, et al.The Emerging Role of Central and Peripheral Immune Systems in Neurodegenerative Diseases[J]. Frontiers in Aging Neuroscience, 2022, 14: 872134.
[28] ASSOGNA M, DI LORENZO F, MARTORANA A, et al.Synaptic Effects of Palmitoylethanolamide in Neurodegenerative Disorders[J]. Biomolecules, 2022, 12(8): 1161.
[29] AL TAHAN MA, MARWAH MK, DHALIWAL M, et al.Novel AP39-Loaded Liposomes Sustain the Release of Hydrogen Sulphide, Enhance Blood-Brain Barrier Permeation, and Abrogate Oxidative Stress-Induced Mitochondrial Dysfunction in Brain Cells[J]. Drug Design, Development and Therapy, 2025, 19: 2067-2079.
[30] HU W, WANG M, SUN G, et al.RND3 Modulates Microglial Polarization and Alleviates Neuroinflammation in Parkinson's Disease by Suppressing NLRP3 Inflammasome Activation[J]. Experimental Cell Research, 2024, 439(1): 114088.
[31] WANG J, MENG XH, CHAI T, et al.Diterpenoid Alkaloids and one Lignan from the Roots of Aconitum pendulum Busch[J]. Natural Products and Bioprospecting, 2019, 9(6): 419-423.
[32] VAZQUEZ T, PATEL J, KODALI N, et al. Plasmacytoid Dendritic Cells Are Not Major Producers of Type 1 IFN in Cutaneous Lupus: an In-Depth Immunoprofile of Subacute and Discoid Lupus[J]. The Journal of Investigative Dermatology, 2024, 144(6): 1262-1272. e7.
[33] MASOUMI M, ALESAEIDI S, KHORRAMDELAZAD H, et al.Role of T Cells in the Pathogenesis of Rheumatoid Arthritis: Focus on Immunometabolism Dysfunctions[J]. Inflammation, 2023, 46(1): 88-102.
[34] ROTH A, BARCELLINI W, D'SA S, et al. Sustained Inhibition of Complement C1s with Sutimlimab over 2 Years in Patients with Cold Agglutinin Disease[J]. American Journal of Hematology, 2023, 98(8): 1246-1253.
[35] WAN ZL, ZHANG M, XIAO Y, et al.C-Diterpenoid Alkaloids from Aconitum refractum var. Circinatum[J]. Natural Product Research, 2024, 38(18): 3201-3206.
[36] DING N, WANG S, XIAO Y, et al.Four New C₁₉ -Diterpenoid Alkaloids from Aconitum nagarum Stapf[J]. Chemistry & Biodiversity, 2023, 20(5): e202300058.
[37] DUAN XY, ZHAO DK, SHEN Y.Two new bis-C₂₀-Diterpenoid Alkaloids with Anti-Inflammation Activity from Aconitum bulley-anum[J]. Journal of Asian Natural Products Research, 2019, 21(4): 323-330.
[38] ZENG XZ, HE LG, WANG S, et al.Aconine Inhibits RANKL-Induced Osteoclast Differentiation in RAW264.7 Cells by Suppressing NF-κB and NFATc1 Activation and DC-STAMP Expression[J]. Acta Pharmacologica Sinica, 2016, 37(2): 255-263.
[39] GUO C, HE L, HU N, et al.Aconiti Lateralis Radix Praeparata Lipid-Soluble Alkaloids Alleviates IL-1β-Induced Inflammation of Human Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Inhibiting NF-κB and MAPKs Signaling Pathways and Inducing Apoptosis[J]. Cytokine, 2022, 151: 155809.
[40] WU Y, LIU Y, ZHANG L, et al.Aconiti Lateralis Radix Praeparata Total Alkaloids Exert Anti-RA Effects by Regulating NF-κB and JAK/STAT Signaling Pathways and Promoting Apoptosis[J]. Frontiers in Pharmacology, 2022, 13: 980229.
[41] XIAO Y, HAN M, CHEN Y, et al.In vitro and in vivo Biological Evalu-ation of Lappaconitine Derivatives as Potential Anti-Inflammatory Agents[J]. Chemistry & Biodiversity, 2024, 21(2): e202301761.
[42] RUI Y, ZHANG X, MIN X, et al.Unlocking Renal Restoration: Mesaconine from Aconitum Plants Restore Mitochondrial Function to Halt Cell Apoptosis in Acute Kidney Injury[J]. International Immuno-pharmacology, 2024, 133: 112170.
[43] HE JB, LUAN J, LV XM, et al.Navicularines A-C: New Diterpenoid Alkaloids from Aconitum Naviculare and Their Cytotoxic Activities[J]. Fitoterapia, 2017, 120: 142-145.
[44] JIANG H, HUANG S, GAO F, et al.Diterpenoid Alkaloids from Aconitum brevicalcaratum as Autophagy Inducers[J]. Natural Product Research, 2019, 33(12): 1741-1746.
[45] LI X, HU J, TONG D, et al.Inhibitory Effect of Aconitine on Colorectal Cancer Malignancy via Inducing Apoptosis and Suppression of Cell Motion[J]. The Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology, 2024, 36(1): 53-60.
[46] FENG HT, ZHAO WW, LU JJ, et al.Hypaconitine Inhibits TGF-β1-Induced Epithelial-Mesenchymal Transition and Suppresses Adhesion, Migration, and Invasion of Lung Cancer A549 Cells[J]. Chinese Journal of Natural Medicines, 2017, 15(6): 427-435.
[47] QI XZ, WANG L, WANG H, et al.Aconitine Inhibits the Proliferation of Hepatocellular Carcinoma by Inducing Apoptosis[J]. International Journal of Experimental Pathology, 2018, 11(11): 5278-5289.
[48] YIN TP, CAI L, ZHOU H, et al.A new C19-Diterpenoid Alkaloid from the Roots of Aconitum duclouxii[J]. Natural Product Research, 2014, 28(19): 1649-1654.
[49] YU J, YIN TP, WANG JP, et al.A new C₂₀-Diterpenoid Alkaloid from the Lateral Roots of Aconitum carmichaeli[J]. Natural Product Research, 2017, 31(2): 228-232.
[50] HU ZX, AN Q, TANG HY, et al.Acoapetaludines A-K, C₂₀- and C₁₉-Diterpenoid Alkaloids from the Whole Plants of Aconitum apetalum (Huth) B.Fedtsch[J]. Phytochemistry, 2019, 167: 112111.
[51] ANMOL KS, KUMAR R, SINGH R, et al.Antiplasmodial Diter-penoid Alkaloid from Aconitum heterophyllum Wall. ex Royle: Isolation, Characterization, and UHPLC-DAD BASED QUANTIFICation[J]. Journal of Ethnopharmacology, 2022, 287: 114931.
[52] HELLER CD, ZAHEDIFARD F, DOSKOCIL I, et al.Traditional Medicinal Ranunculaceae Species from Romania and Their in vitro Antioxidant, Antiproliferative, and Antiparasitic Potential[J]. International Journal of Molecular Sciences, 2024, 25(20): 10987.
[53] LAWSON C, McCABE DJ, FELDMAN R. A Narrative Review of Aconite Poisoning and Management[J/OL]. Journal of Intensive Care Medicine, (2024-04-13)[2025-05-20]. https://pubmed.ncbi.nlm.nih.gov/38613376/.
[54] LIU F, TAN XX, HAN X, et al.Cytotoxicity of Aconitum Alkaloid and Its Interaction with Calf Thymus DNA by Multi-Spectroscopic techniques[J]. Scientific Reports, 2017, 7(1): 14509.
[55] JIANG H, ZHANG Y, ZHANG Y, et al.An Updated Meta-Analysis Based on the Preclinical Evidence of Mechanism of Aconitine-Induced Cardiotoxicity[J]. Frontiers in Pharmacology, 2022, 13: 900842.
[56] LIU X, YANG L, ZHOU R,et al.The Inhibition of PPARα Protein Degradation Alleviates the Cardiotoxicity of Tiebangchui by Regulating Fatty Acid Metabolism[J]. Journal of Ethnopharmacology, 2025, 348: 119838.
[57] GAO XT, ZANG XC, HU J, et al.Aconitine Induces Apoptosis in H9c2 Cardiac Cells via Mitochondria-Mediated Pathway[J]. Molecular Medicine Reports, 2018, 17(1): 284-292.
[58] PENG F, ZHANG N, WANG CT, et al.Aconitine Induces Cardiomyocyte Damage by Mitigating BNIP3-Dependent Mitophagy and the TNFα-NLRP3 Signalling Axis[J]. Cell Proliferation, 2020, 53(1): e12701.
[59] LIU F, HAN X, LI N, et al.Aconitum Alkaloids Induce Cardiotoxicity and Apoptosis in Embryonic Zebrafish by Influencing the Expression of Cardiovascular Relative Genes[J]. Toxicology Letters, 2019, 305: 10-18.
[60] GE YX, WANG YG, ZHANG Z, et al.Effect of Hypaconitine of Radix Aconiti Carmichaeli on hERG Channels in Cardiac Myocytes via miR-134 Regulation[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2024, 21(6): 606-610.
[61] COULSON JM, CAPARROTTA TM, THOMPSON JP.The Management of Ventricular Dysrhythmia in Aconite Poisoning[J]. Clinical Toxicology (Philadelphia, Pa.), 2017, 55(5): 313-321.
[62] HUANG R, PANG Q, ZHENG L, et al.Acute aconitine Poisoning Resulting from the Ingestion of Medicinal Liquor[J]. Journal of Forensic Sciences, 2024, 69(6): 2317-2324.
[63] YANG HQ, WANG H, LIU YB, et al.The PI3K/Akt/mTOR Signaling Pathway Plays a Role in Regulating Aconitine-Induced Autophagy in Mouse Liver[J]. Research In Veterinary Science, 2019, 124: 317-320.
[64] WANG H, LIU Y, GUO Z, et al.Aconitine Induces Cell Apoptosis via Mitochondria and Death Receptor Signaling Pathways in Hippocampus Cell Line[J]. Research in Veterinary Science, 2022, 143: 124-133.
[65] CONG JJ, RUAN YL, LYN QL, et al.A Proton-Coupled Organic Cation Antiporter is Involved in the Blood-Brain Barrier Transport of Aconitum Alkaloids[J]. Journal of Ethnopharmacology, 2020, 252: 112581.
[66] ZHANG Y, ZHANG TJ, LI XY, et al.2-((1-Phenyl-1H-1,2,3-triazol-4-yl)methyl)-2-azabicyclo[3.2.1]octan-3-one Derivatives: Simplification and Modification of Aconitine Scaffold for the Discovery of Novel Anticancer Agents[J]. European Journal of Medicinal Chemistry, 2021, 210: 112988.
[67] ZHANG N, LIAN Z, PENG X, et al.Applications of Higenamine in Pharmacology and Medicine[J]. Journal of Ethnopharmacology, 2017, 196: 242-252.
[68] ZONG XX, YAN XJ, WU JL, et al.Potentially Cardiotoxic Diterpenoid Alkaloids from the Roots of Aconitum Carmichaelii[J]. Journal of Natural Products, 2019, 82(4): 980-989.
[69] LI HC, GE YX, WANG NN, et al.Research Progress in Roles of Ginseng Combined with Radix Aconiti Carmichaeli in Reducing Toxicity and Increasing Efficiency in Myocardial Cells[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2024, 21(6): 601-605.

乌头属二萜生物碱的药理学与毒理学作用及挑战

Effects and Challenges of Pharmacology and Toxicology of Aconitum Diterpenoid Alkaloids

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	陈润吉, 孙小蕊, 黄鑫, 江振洲, 张陆勇, 王欣之, 丁健. 雷公藤甲素肝毒性中NK细胞的动态免疫表型研究[J]. 中国药物警戒, 2025, 22(5): 517-522.
[2]	杨静琦, 许保海, 张静, 姜洋, 侍方. 骨伤科中成药用药警戒[J]. 中国药物警戒, 2025, 22(4): 436-441.
[3]	卜子轩, 薛梦微, 田佳微, 柯凯乐, 王紫颖, 李潇, 卢天公. 桂枝茯苓丸干预卵巢癌干细胞特性的作用及机制研究[J]. 中国药物警戒, 2025, 22(3): 263-270.
[4]	唐千茴, 张昊然, 张陆勇, 江振洲. 雷公藤甲素肝损伤研究进展[J]. 中国药物警戒, 2025, 22(2): 121-127.
[5]	甘叶娜, 韩晟, 苑艺, 薛丽娟, 黄昊雯, 李欢欣, 张心慈, 奎思怡, 孟博斐, 李奇霏, 阿那古·吐地, 刘志凤, 秦灵灵, 李多多. 基于网络药理学探讨大承气汤改善退行性腰椎管狭窄症主观症状的分子机制研究[J]. 中国药物警戒, 2025, 22(2): 162-168.
[6]	王萍, 曹卉娟, 李梦琪, 张国治, 刘建平, 金雪晶. “乌头-半夏”反药配伍对大鼠毒性研究的系统评价和Meta分析[J]. 中国药物警戒, 2025, 22(2): 177-182.
[7]	郑海云, 张雯, 王少南, 赵海誉, 杜守颖. 人参联合咖啡因对大鼠的抗疲劳作用及机制探讨[J]. 中国药物警戒, 2024, 21(8): 863-870.
[8]	张凯华, 刘丁维, 付长海, 孙雪林, 闵先军. 罗沙司他联合当归补血汤对AR和NR3C2基因表达的影响[J]. 中国药物警戒, 2024, 21(8): 871-877.
[9]	刘亚迪, 张晓朦, 蔡海丽, 陈思颖, 王雨, 张冰. 阿霉素心脏毒性的中药防治用药分析及证素实证研究[J]. 中国药物警戒, 2024, 21(7): 759-764.
[10]	蔡海丽, 张晓朦, 刘亚迪, 刘淑佳, 高福君, 王雨, 张冰. 药源性心脏毒性模型的构建与评价进展[J]. 中国药物警戒, 2024, 21(7): 765-770.
[11]	胡笑文, 张才煜, 王峰峰, 濮恒婷, 刘阳, 陈华. 基于规定日服用剂量改进药物肝毒性预测方法的研究[J]. 中国药物警戒, 2024, 21(7): 776-780.
[12]	李鸿昌, 葛运炫, 王宁宁, 周维, 王宇光, 马增春, 高月. 参附配伍对心肌细胞减毒增效作用[J]. 中国药物警戒, 2024, 21(6): 601-605.
[13]	葛运炫, 王宇光, 张卓, 马增春, 高月. 附子中次乌头碱调控miR-134对心肌细胞hERG通道的影响[J]. 中国药物警戒, 2024, 21(6): 606-610.
[14]	敖婷, 王宁宁, 周磊, 邓慧芳, 杨兴鑫, 周维, 沈磐, 高月. 基于临床用药特点的补骨脂斑马鱼肝毒性确证与机制探讨[J]. 中国药物警戒, 2024, 21(6): 611-616.
[15]	李心蕾, 贡磊磊, 王晓霞, 张雪艳, 赵涵, 姚伟洁, 袁偲偲, 冯欣. 基于网络药理学和分子对接探讨养血安胎颗粒治疗复发性流产分子作用机制[J]. 中国药物警戒, 2024, 21(4): 366-370.