罗沙司他胶囊致肾性贫血患者阵发震颤1例分析

doi:10.19803/j.1672-8629.20250121

中国药物警戒 ›› 2025, Vol. 22 ›› Issue (12): 1434-1436.
DOI: 10.19803/j.1672-8629.20250121

罗沙司他胶囊致肾性贫血患者阵发震颤1例分析

张天续¹, 王绍华^1*, 张婧², 王子薇¹, 张国治¹

¹中国中医科学院望京医院血液净化中心,北京 100102;
²中国中医科学院望京医院药学部,北京 100102

收稿日期:2025-02-28 发布日期:2025-12-19
通讯作者: ^*王绍华,女,硕士,主任医师,中西医结合临床医学。E-mail: shaohua_wang2009@163.com
作者简介:张天续,男,在读硕士,中西医结合临床医学。

One Case of Paroxysmal Tremor in a Patient with Renal Anemia Caused by Roxadustat Capsules

ZHANG Tianxu¹, WANG Shaohua^1*, ZHANG Jing², WANG Ziwei¹, ZHANG Guozhi¹

¹Blood Purification Center, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China;
²Department of Pharmacy, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China

Received:2025-02-28 Published:2025-12-19

摘要/Abstract

摘要： 目的分析罗沙司他胶囊致阵发震颤不良反应病例,为临床安全使用提供参考。方法梳理1例老年慢性肾脏病（CKD）5期患者使用罗沙司他胶囊治疗肾性贫血出现阵发震颤的病例,参考国内外文献,探讨其可能机制和治疗措施。结果 CKD5期老年患者常规剂量服用罗沙司他胶囊出现阵发震颤,停用罗沙司他胶囊后震颤未再发作,经关联性评价,推测患者震颤可能由罗沙司他胶囊所致。结论临床应加强罗沙司他胶囊治疗老年肾性贫血导致震颤不良反应的重视,做到尽早识别并及时干预,防止严重不良反应的发生。

关键词: 罗沙司他, 震颤, 慢性肾脏病, 肾性贫血, 药品不良反应

Abstract: Objective To analyze one case of paroxysmal tremor associated with roxadustat capsules in order to provide data for clinical safety. Methods The clinical data of an elderly patient with stage 5 chronic kidney disease (CKD5) was studied, who developed paroxysmal tremor during roxadustat therapy for renal anemia. Literature was reviewed to find out about the incidence, potential mechanisms, and management strategies of tremor induced by roxadustat. Results The patient presented with recurrent tremor following standard-dose roxadustat administration, which was resolved completely after drug discontinuation. Based on causality assessment, the tremor was likely attributed to roxadustat capsule administration. Conclusion Clinicians should remain alert to tremor-related adverse drug reactions in elderly patients receiving roxadustat for renal anemia. Early detection and prompt interventions are critical to mitigating severe neurological complications.

Key words: Roxadustat, Tremor, Chronic Kidney Disease, Renal Anemia, Adverse Drug Reactions

中图分类号:

R983
R994.11

张天续, 王绍华, 张婧, 王子薇, 张国治. 罗沙司他胶囊致肾性贫血患者阵发震颤1例分析[J]. 中国药物警戒, 2025, 22(12): 1434-1436.

ZHANG Tianxu, WANG Shaohua, ZHANG Jing, WANG Ziwei, ZHANG Guozhi. One Case of Paroxysmal Tremor in a Patient with Renal Anemia Caused by Roxadustat Capsules[J]. Chinese Journal of Pharmacovigilance, 2025, 22(12): 1434-1436.

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罗沙司他胶囊致肾性贫血患者阵发震颤1例分析

One Case of Paroxysmal Tremor in a Patient with Renal Anemia Caused by Roxadustat Capsules

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