中国药物警戒 ›› 2025, Vol. 22 ›› Issue (10): 1171-1173.
DOI: 10.19803/j.1672-8629.20240655

• 安全与合理用药 • 上一篇    下一篇

司美格鲁肽注射液致严重腹泻1例分析

卫晋菲1,2, 纪立伟2,*   

  1. 1解放军总医院医疗保障中心药剂科,北京 100853;
    2北京医院药学部国家老年医学中心,中国医学科学院老年医学研究院北京市药物临床风险与个体化应用评价重点实验室,北京 100730
  • 收稿日期:2024-08-27 出版日期:2025-10-15 发布日期:2025-10-20
  • 通讯作者: *纪立伟,女,硕士,主任药师,临床药学。E-mail: jlw1228@sina.com
  • 作者简介:卫晋菲,女,本科,主管药师,临床药学。

One Case of Severe Diarrhea Caused by Semaglutide Injection

WEI Jinfei1,2, JI Liwei2,*   

  1. 1Department of Pharmacy, Medical Supplies Center, Chinese PLA General Hospital, Beijing 100853, China;
    2Department of Pharmacy, Beijing Hospital, National Center of Gerontology Institute of Geriatric Medicine, Chinese Academy of Medical Science Beijing Key Laboratory of Assessment for Clinical Risk and Individual Application of Drugs, Beijing 100730, China
  • Received:2024-08-27 Online:2025-10-15 Published:2025-10-20

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摘要： 目的 探讨司美格鲁肽注射液致严重腹泻的不良反应,为临床合理使用司美格鲁肽注射液提供参考。方法 分析1例由司美格鲁肽注射液导致严重腹泻的患者诊疗经过、危险因素、可能机制及治疗策略。结果 在住院期间患者接受2次司美格鲁肽注射液（0.5 mg）治疗后,出现严重腹泻,对症治疗后症状得到缓解。出院后再次使用司美格鲁肽注射液（0.5 mg）,再次出现严重腹泻,停药后症状好转。结论 临床使用应按说明书规定从低剂量开始,加强司美格鲁肽注射液致腹泻不良反应的重视,当不良反应出现时,应及时干预。

关键词: 司美格鲁肽, 注射液, 严重, 腹泻, 焦虑, 药品不良反应

Abstract: Objective To analyze one case of severe diarrhea induced by semaglutide injection and to provide clinical physicians with references for its rational use. Methods Based on findings of research currently available, the diagnostic and therapeutic process, risk factors, potential mechanisms and treatment strategies related to a patient with severe diarrhea that was considered to have been caused by semaglutide injection were analyzed. Results During hospitalization, the patient experienced severe diarrhea after receiving two doses of semaglutide injection (0.5 mg). The symptoms were alleviated following symptomatic treatment. After discharge, severe diarrhea recurred when the patient was readministered with semaglutide injection (0.5 mg). The symptoms abated after discontinuation of medication. Conclusion Clinicians should initiate semaglutide injection at a low dose as instructed. Particular attention should be paid to such adverse reactions as diarrhea induced by semaglutide injection. Prompt interventions are warranted once such adverse events occur.

Key words: Semaglutide, Injection, Severe, Diarrhea, Anxiety, Adverse Drug Reactions

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