中国药物警戒 ›› 2024, Vol. 21 ›› Issue (12): 1393-1397.
DOI: 10.19803/j.1672-8629.20240637

• 中药治疗脑卒中研究进展专栏 • 上一篇    下一篇

缺血性脑卒中模型研究进展

刘柘君1,2, 唐田3, 谭天阳4, 白雪1,*   

  1. 1中国中医科学院医学实验中心, 北京市中医药防治重大疾病基础研究重点实验室,北京 100700;
    2首都医科大学中医药学院,北京100026;
    3中国科学院北京基因组研究所,北京,100101;
    4中国中医科学院西苑医院康复医学科,北京100091
  • 收稿日期:2024-08-23 出版日期:2024-12-15 发布日期:2024-12-16
  • 通讯作者: *白雪,女,博士,助理研究员,中药防治脑血管疾病。E-mail: dr.baixue@hotmail.com
  • 作者简介:刘柘君,女,在读博士,中医药治疗脑血管疾病。
  • 基金资助:
    中国中医科学院西苑医院院级师承项目（YJMPS- C202437）; 国家自然科学基金资助项目（82304767）; 中央级公益性科研院所基本科研业务费专项基金（JJPY2022021、ZZ15- YQ-055）; 中国中医科学院科技创新工程项目（CI2021B017）

Research Progress on Models of Ischemic Stroke

LIU Zhejun1,2, TANG Tian3, TAN Tianyang4, BAI Xue1,*   

  1. 1Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment of Major Disease, Beijing 100700, China;
    2School of Traditional Chinese Medicine, Capital Medical University, Beijing 100026, China;
    3Chinese Academy of Sciences (CAS) Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China;
    4Rehabilitation Medicine Department of Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100091, China
  • Received:2024-08-23 Online:2024-12-15 Published:2024-12-16

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摘要： 目的 深入了解缺血性脑卒中的疾病机制、评估治疗效果和预测预后结果。方法 综述缺血性脑卒中研究中的临床模型、药理模型（包括体内和体外）以及其他新兴模型的最新研究内容。结果 通过梳理缺血性脑卒中相关临床模型,发现其研究主要聚焦于风险预测、预后评估和治疗决策支持;药理模型在机制探索和药物筛选方面发挥了重要作用;新兴的计算机模型和多组学模型为个体化治疗和精准医疗提供了新的思路。结论 尽管现有的缺血性脑卒中模型在研究中取得了一定的进展,但仍面临着临床相关性、模型整合和转化应用等挑战。未来研究应致力于提高模型的准确性和普适性,加强多学科合作,促进基础研究向临床实践的转化,进一步改善缺血性脑卒中患者的诊疗效果和生活质量。

关键词: 缺血性脑卒中, 临床模型, 药理模型, 体内模型, 体外模型, 计算机模型

Abstract: Objective To find out more about the disease mechanism of ischemic stroke, evaluate the therapeutic efficacy and predict prognosis. Methods The latest progress in clinical models, pharmacological models (including in vivo and in vitro models), and other emerging models related to ischemic stroke research was summarized. Results Clinical models were mostly used for risk prediction, prognosis assessment, and treatment decision support. Pharmacological models played a crucial role in mechanism exploration and drug screening. Emerging computer models and multi-omics models offered new perspectives for personalized treatments and precision medicine. Conclusion Despite significant advancements in ischemic stroke research, these models are still facing challenges related to clinical relevance, model integration, and translational applications. Future research should try to work on the accuracy and generalizability of models, strengthen multidisciplinary collaboration, and promote the translation of basic research into clinical practices in order to improve diagnosis, treatments, and quality of life for patients with ischemic stroke.

Key words: Ischemic Stroke, Clinical Models, Pharmacological Models, In Vivo Models, In Vitro Models, Computer Models

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