中国药物警戒 ›› 2022, Vol. 19 ›› Issue (1): 47-51.
DOI: 10.19803/j.1672-8629.2022.01.10

• 真实世界老年/儿童患者应用中成药的现状研究专栏 • 上一篇    下一篇

真实世界喜炎平注射液治疗儿童肺炎联合用药特征研究

苏鑫鑫1, 李利寻1, 王志飞1#, 谢雁鸣1,*, 王淇2   

  1. 1中国中医科学院中医临床基础医学研究所,北京 100700;
    2中国人民大学统计学院,北京 100872
  • 收稿日期:2021-04-19 出版日期:2022-01-15 发布日期:2022-01-20
  • 通讯作者: *谢雁鸣,女,首席研究员·博导,中医临床评价方法。E-mail：ktzu2018@163.com。#为共同通信作者。
  • 作者简介:苏鑫鑫,女,本科,中成药上市后评价。
  • 基金资助:
    国家重点研发计划（2018YFC1707410）

Real-world study on Xiyanping injection combined in the treatment of childhood pneumonia

SU Xinxin1, LI Lixun1, WANG Zhifei1#, XIE Yanming1,*, WANG Qi2   

  1. 1Institute of Basic Research in Clinical Medicine, China Academy of Chinese Sciences, Beijing 100700, China;
    2School of statistics, Renmin University of China, Beijing 100872, China
  • Received:2021-04-19 Online:2022-01-15 Published:2022-01-20

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摘要： 目的 分析真实世界中喜炎平注射液联合用药治疗肺炎患儿的用药特征。方法 基于2006年12月1日至2016年6月30日全国29家三级甲等医院信息管理系统（HIS）数据库和实验室（检验科）信息系统（LIS）数据库,采用Apriori算法建立模型和Clementine 12.0进行关联分析,对使用喜炎平注射液的35 233例患儿人群特征和联合用药情况进行分析。结果 患儿年龄0~3岁（82.83%）占比最大;真实世界中儿童人群使用喜炎平注射液多应用于一般病情;住院天数4~14 d占比最大;喜炎平注射液静脉单次每日给药剂量50~100 mg占比最大;主要用于西医诊断为支气管肺炎,中医诊断主病肺炎喘咳病,主证痰热、风热;喜炎平注射液一般联合氨溴索（美舒咳）黏液溶解药,布地奈德皮质甾体激素类,沙丁胺醇选择性β2-肾上腺素受体促效药,异丙托溴铵抗胆碱能药使用最常见。结论 在治疗儿童肺炎患者时常用喜炎平注射液与黏液溶解药、皮质甾体激素类、选择性β2-肾上腺素受体促效药和抗胆碱能药类化学药品联合使用,为临床合理使用喜炎平注射液提供参考。

关键词: 喜炎平注射液, 儿童患者, 真实世界, 联合用药, 临床治疗

Abstract: Objective To analyze the medication characteristics of Xiyanping injection combined in the treatment of children with pneumonia in the real world. Methods Based on HIS and LIS database of hospitalized patients from 29 hospitals in China from December 1, 2006 to June 30, 2016, the Apriori algorithm was conducted to establish the model and clementine 12.0 was conducted to analyze the characteristics and combination medication of 35 233 children who received Xiyanping injection with pneumonia. Results Children aged 0~3 years (82.83%) accounted for the largest proportion; In the real world, Xiyanping injection is mainly used for children with general conditions; The number of days in hospital was 4~14 days; For Xiyanping injection, the single intravenous dose per day was 50~100 mg; The main diagnosis of Western medicine was bronchial pneumonia, and the main diagnosis of Traditional Chinese medicine was pneumonia, asthma and cough, and the main syndromes were phlegm-heat and wind-heat; Xiyanping injection is generally combined with ambroxol (methusol) mucus dissolver, budesonide corticosteroid hormone, salbutamol selective β2-adrenergic receptor stimulant, and ipratropium bromide anticholinergic drug. Conclusion Xiyanping injection is often used in combination with mucolysis drugs, corticosteroid hormones, selective β2-adrenergic receptor promoters and anticholinergic chemicals in the treatment of children with pneumonia to provide a reference for the rational use of Xiyanping injection in clinical practice.

Key words: Xiyanping injection, children, real-world, combination drug use, clinical treatment

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