969例环磷腺苷葡胺注射剂不良反应报告分析

中国药物警戒 ›› 2018, Vol. 15 ›› Issue (8): 481-484.

969例环磷腺苷葡胺注射剂不良反应报告分析

刘赛月, 胡婷霞

浙江省药品不良反应监测中心,浙江杭州 310012

收稿日期:2018-10-11 修回日期:2018-10-11 出版日期:2018-08-20 发布日期:2018-10-11
作者简介:刘赛月,女,硕士,主管药师,药品不良反应监测与评价。

Analysis of 969 Cases of Adverse Drug Reactions Caused by Meglumine Adenosine Cyclophosphate Injection

LIU Saiyue, HU Tingxia

Zhejiang Center for ADR Monitoring, Zhejiang Hangzhou 310012, China

Received:2018-10-11 Revised:2018-10-11 Online:2018-08-20 Published:2018-10-11

摘要/Abstract

摘要： 目的探讨环磷腺苷葡胺注射剂致不良反应的特点及其可能的原因,为临床安全合理用药提供参考。方法采用回顾性分析方法,对浙江省ADR 数据库中2010年1月- 2017年2月上报的969例环磷腺苷葡胺注射剂不良反应报告,分别按不良反应类型、报告数量趋势、患者性别、年龄、原患疾病、用药情况、不良反应表现等进行统计和分析。结果环磷腺苷葡胺注射剂新的不良反应占58%,以45岁以上的患者居多（85.45%）;不良反应累及系统-器官主要为全身性反应、消化系统和皮肤及其附件,严重不良反应累及系统-器官主要为全身性反应、皮肤及其附件和呼吸系统。结论临床应重视环磷腺苷葡胺注射剂引起的不良反应,尤其是过敏性休克等严重不良反应;生产企业应完善药品说明书安全性信息,加强临床合理用药,保障用药安全。

关键词: 环磷腺苷葡胺, 注射剂, 药品不良反应, 报告, 安全用药

Abstract: Objective To investigate the occurrence and characteristics of adverse drug reactions(ADR_s) caused by meglumine adenosine cyclophosphate injection, so as to provide reference for rational drug use in the clinic. Methods The retrospective study method was used to analyze 969 cases of ADR_s caused by meglumine adenosine cyclophosphate injection. These ADR_s were collected by Zhejiang ADR_s monitoring system from Jan.2010 to Feb.2017.The analysis includes the type of reports, quantity trends, the case of gender, age, medication situation and adverse drug reactions. Results 54% cases were new ADR reports. ADR_s caused by meglumine adenosine cyclophosphate injection mostly occurred in the patients aged above 45 years old(85.45%). The SOC_s mostly involved in ADRs were systemic reaction, the digestive system, skin and its accessories. The serious ADR_s involving SOC_s were mainly systemic reaction, skin and its accessories, and respiratory system. Conclusion More attention should be paid to ADRs caused by meglumine adenosine cyclophosphate injection in clinic, especially the serious adverse reactions such as allergic shock. Drug manufacturers should promptly improve the safety information of drug instructions．The rational drug use should be strengthened to improve the safety of drug use in patients.

Key words: meglumine adenosine cyclophosphate, injection, adverse drug reaction, reports, safe drug use

中图分类号:

R994.11

刘赛月, 胡婷霞. 969例环磷腺苷葡胺注射剂不良反应报告分析[J]. 中国药物警戒, 2018, 15(8): 481-484.

LIU Saiyue, HU Tingxia. Analysis of 969 Cases of Adverse Drug Reactions Caused by Meglumine Adenosine Cyclophosphate Injection[J]. Chinese Journal of Pharmacovigilance, 2018, 15(8): 481-484.

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