中国药物警戒 ›› 2018, Vol. 15 ›› Issue (2): 110-115.

• 安全与合理用药 • 上一篇    下一篇

890例碘海醇注射液不良反应数据分析

林京玉, 钟蕾, 邢丽秋, 刘东红*   

  1. 北京市药品不良反应监测中心，北京 100035
  • 收稿日期:2017-11-01 修回日期:2018-03-28 出版日期:2018-02-20 发布日期:2018-03-28
  • 通讯作者: 刘东红，女，副主任药师，药品不良反应监测及药物警戒。E-mail:13601236723@163.com
  • 作者简介:林京玉，女，博士，药品不良反应监测及药物警戒。

Analysis of 890 Cases of Adverse Reactions Induced by Iohexol Injection

LIN Jing-yu, ZHONG Lei, XING Li-qiu, LIU Dong-hong*   

  1. Beijing Center for ADR Mornitoring, Beijing 100035, China
  • Received:2017-11-01 Revised:2018-03-28 Online:2018-02-20 Published:2018-03-28

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摘要： 目的 分析碘海醇注射液药品不良反应（ADR）报告数据，了解该药ADR发生的特点，为临床安全合理用药提供参考。方法 检索并整理2003年至2016年北京市药品不良反应监测中心收集到的碘海醇注射液ADR报告，对其进行统计分析。结果 共有890例ADR报告纳入分析，ADR报告数量有逐年增高的趋势，ADR主要发生在40岁以上人群，累及系统-器官损害以皮肤及附件损害、消化系统损害、全身性损害为主。共有60例严重不良反应，主要表现为过敏性休克、过敏样反应、肾功能异常、失语症等，其中死亡7例。结论 加强碘海醇注射液的临床安全合理使用，提高严重不良反应的识别和救治能力。

关键词: 碘海醇注射液, 药品不良反应, 分析, 合理用药

Abstract: Objective A data analysis of the adverse drug reactions (ADRs) induced by iohexol injection was conducted to understand the characteristics of The ADRs and provide technical support for the clinical safe use of the drug. Methods A total of 890 ADR reports collected by the Beijing Center for ADR Monitoring on iohexol injection inducing ADRs between 2003 and 2016 were sorted out and analyzed. Results ADRs, being on the increase year by year, mainly occur in people over the age of 40. Systems and organs affected by ADRs were mainly observed to be skin and appendages disorders, gastrointestinal disorders, and systematic disorders. A total of 60 cases of severe ADRs, including 7 cases of death, occurred, where anaphylactic shock, anaphylactic reaction, renal impairment, aphasia were the typical manifestations. Conclusion It is important that sufficient attention be paid to ADRs caused by iohexlo injection, with special focus on improving the ability to identify and treat severe ADRs.

Key words: iohexol injection, adverse drug reaction, analysis, rational use of drug

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