中国药物警戒 ›› 2018, Vol. 15 ›› Issue (1): 45-48.

• 安全与合理用药 • 上一篇    下一篇

141例低分子右旋糖酐氨基酸不良反应报告分析

王琳1, 李双2, 李华彬3, 鞠永静2   

  1. 1 山东省临沂市中心医院疼痛科,山东 临沂 276400;
    2 山东省临沂市中心医院药学部,山东 临沂 276400;
    3 山东省临沂市药品不良反应监测中心,山东 临沂 276000;
  • 收稿日期:2018-02-12 修回日期:2018-02-12 出版日期:2018-01-20 发布日期:2018-02-12
  • 作者简介:王琳,男,本科,主治医师,疼痛科。

Analysis of Adverse Drug Reactions about 141 Cases of Dextran 40 and Amino Acids Injection

WANG Lin1, LI Shuang2, LI Hua-bin3, JU Yong-jing2   

  1. 1 Department of Pain Management, LinYi Central Hospital, Shandong Linyi 276400, China;
    2 Department of Pharmacy, Shandong LinYi Central Hospital, Shandong Linyi 276400, China;
    3 Center for Adverse Drug Reaction Monitoring, Shandong Linyi 276000, China;
  • Received:2018-02-12 Revised:2018-02-12 Online:2018-01-20 Published:2018-02-12

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摘要： 目的 总结分析低分子右旋糖酐氨基酸不良反应（ADR）发生的规律与特点,促进临床合理用药,保障患者用药安全。方法 登陆国家药品不良反应监测系统,汇总统计我院2010年1月至2017年6月上报的141例低分子右旋糖酐氨基酸注射液的ADR,分别从患者年龄、性别、科室分布、发生时间、临床表现、严重的ADR及近几年的上报数量进行统计分析。结果 141例ADR报告中,女性患者多于男性,21~40岁的患者占58.87%,45.71%的病例来源于产科,92.91%的患者在开始用药后30 min内发生不良反应,其中首次应用药物即出现不良反应的患者占61.70%,ADR表现类型主要为皮肤及其附件损害（24.9%）和呼吸系统损害（23.69%）,严重的ADR 43例（占30.50%）,2017年上半年上报ADR的例数增多。结论 低分子右旋糖酐氨基酸ADR发生率高,应用风险高,临床医务人员必须重视该药的不良反应,严格掌握药物的应用指征,尽量减少不良反应的发生。

关键词: 低分子右旋糖酐氨基酸, 过敏性休克, 药品不良反应, 分析

Abstract: Objective To analyze adverse drug reactions(ADRs) of dextran 40 and amino acids injection(DAAI) reported by safety monitoring system in our hospital and promote clinical rational use of drugs. Methods From January 2010 to June 2017, there are totally 141 cases of ADRs, they were analyzed in respects of the patients' age, gender, department distribution, occurrence time, ADR manifestations and severity, and the number reported in recent years. Results Of the 141 reports, the ration of female was higher than male who experienced ADRs, 58.87% of patients were between 21 and 40 years old and 45.71% of patients come from obstetrical department. The adverse reactions of DAAI mainly appeared in less 30 minutes on the first day. The most common ADRs occurred in skin and its appendants(24.9%) and respiratory system(23.69%). Serious adverse events occurred in 43 patients(30.50%). The number of ADR reports was increased on the first half of 2017. Conclusion With high incidence and high application risk, the DAAI ' ADR must be drawned attention, and DAAI should be properly used to reduce the adverse reactions.

Key words: dextran 40 and amino acids injection, anaphylactic shock, adverse drug reaction(ADR), analysis

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