咽喉宁口服液用于急、慢性咽炎的药效学研究

中国药物警戒 ›› 2017, Vol. 14 ›› Issue (3): 137-141.

咽喉宁口服液用于急、慢性咽炎的药效学研究

孙静¹, 郭姗姗¹, 赵荣华¹, 陆赛卫², 高英杰¹, 时宇静¹, 崔晓兰^{1, *}

1 中国中医科学院中药研究所,北京 100700;
2 苏州玉森新药开发有限公司,江苏苏州 215001

收稿日期:2017-04-20 修回日期:2017-04-20 出版日期:2017-03-20 发布日期:2017-04-20
通讯作者: 崔晓兰,女,博士,研究员,中药药理学。E-mail: cuixiaolan2812@126.com
作者简介:孙静,女,博士,助理研究员,中药药理学。

Pharmacodynamics Research of Yanhouning Oral Liquid Treatment on Acute or Chronic Pharygitis

SUN Jing¹, GUO Shan-shan¹, ZHAO Rong-hua¹, LU Sai-wei², GAO Ying-jie¹, SHI Yu-jing¹, CUI Xiao-lan^*

1 Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;
2 Suzhou Youseen New Drug R&D Co.Ltd, Jiangsu Suzhou 215001, China;

Received:2017-04-20 Revised:2017-04-20 Online:2017-03-20 Published:2017-04-20

摘要/Abstract

摘要： 目的研究咽喉宁口服液对急、慢性咽炎动物模型的治疗作用。方法采用15%氨水咽部喷雾方法造成大鼠急性咽炎模型,采用2.5%氨水咽部喷雾及黏膜下注射松节油造成家兔慢性咽炎模型,肉眼及镜下观察大鼠和家兔咽部病变情况。采用冰醋酸致小鼠腹腔毛细血管通透性增高、大鼠棉球肉芽肿实验观察其抗炎作用,采用扭体法观察其镇痛作用。结果咽喉宁口服液高、中、低3个剂量组对大鼠及家兔咽部急、慢性病变均有治疗作用;咽喉宁口服液能有效地抑制冰醋酸导致的小鼠腹腔毛细血管通透性增高,减轻大鼠棉球肉芽肿干重量,减少冰醋酸致小鼠的扭体次数。结论咽喉宁口服液对大鼠急性咽炎模型和家兔慢性咽炎模型均具有治疗作用,同时具有抗炎、镇痛的药理作用。

关键词: 咽喉宁口服液, 急性咽炎, 慢性咽炎, 抗炎, 镇痛

Abstract: Objective To evaluate the pharmacodynamic effects of Yanhouning oral liquid (YHNOL) on acute or chronic pharygitis. Methods The protective effect against acute pharyngitis was observed by spraying with 15% ammonia and injecting of beta hemolytic streptococcus at pharyngeal mucosa of rat. The protective effect against chronic pharyngitis was observed by spraying with 2.5% ammonia and injecting of turpentine into pharyngeal mucosa of rabbit. The anti-inflammatory effect was observed by the capillary permeability augmentation of mice induced by acetic acid and cotton pellet granuloma of rats. The analgesic effect was investigated by body twist method. Results Three dose of YHNOL could significantly relieve pharyngeal lesions of rats and rabbits. YHNOL could also significantly inhibit capillary permeability augmentation caused by acetic acid in mice, lighten the dry weight of granuloma induced by cotton ball in rat, depress the torsion body of mice. Conclusion YHNOL could effectively alleviate the symptoms of acute or chronic pharyngitis. It also has significant effect of anti-inflammation and abirritation.

Key words: Yanhouning oral liquid, acute pharyngitis, chronic pharyngitis, anti-inflammatory effect, analgesic effect

中图分类号:

R965

孙静, 郭姗姗, 赵荣华, 陆赛卫, 高英杰, 时宇静, 崔晓兰. 咽喉宁口服液用于急、慢性咽炎的药效学研究[J]. 中国药物警戒, 2017, 14(3): 137-141.

SUN Jing, GUO Shan-shan, ZHAO Rong-hua, LU Sai-wei, GAO Ying-jie, SHI Yu-jing, CUI Xiao-lan. Pharmacodynamics Research of Yanhouning Oral Liquid Treatment on Acute or Chronic Pharygitis[J]. Chinese Journal of Pharmacovigilance, 2017, 14(3): 137-141.

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