中国药物警戒 ›› 2015, Vol. 12 ›› Issue (7): 432-433.

• 医院药事管理与合理用药 • 上一篇    下一篇

临床药师在干预万古霉素血药浓度监测的作用研究

白向荣, 褚燕琦   

  1. 首都医科大学宣武医院药剂科,北京 100053
  • 收稿日期:2015-09-01 修回日期:2015-09-01 出版日期:2015-07-08 发布日期:2015-09-02
  • 作者简介:白向荣,男,硕士,主管药师。

Role of Clinical Pharmacist Intervention in Therapeutic Drug Monitoring of Vancomycin

BAI Xiang-rong, CHU Yan-qi   

  1. Department of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
  • Received:2015-09-01 Revised:2015-09-01 Online:2015-07-08 Published:2015-09-02

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摘要： 目的 研究临床药师在万古霉素血药浓度监测干预中的作用,为临床合理用药提供参考。方法 对我院2011~2013年进行万古霉素血药浓度监测的患者进行分组：不达标组（浓度< 10 μg·mL-1）、达标组（10~20 μg·mL-1）、超过有效范围组（>20μg·mL-1）。同时对临床药师的建议进行统计分析。结果 不达标组：剂量增加比例为3%（3/35）;达标组：剂量无调整比例91%（48/53）;超过有效范围组：剂量减少比例为12.5%（3/24）。结论 临床药师在对万古霉素血药浓度达标组的建议,临床医生采纳较高,对于未达标组和超过有效范围组,临床医生的采纳较低。临床药师加强与临床医生的合作,保证临床的安全、有效用药。

关键词: 万古霉素, 干预, 临床药师

Abstract: Objective To study the role of clinical pharmacists in serum vancomycin concentration monitoring, so as to provide references for rational use of drug service in clinical settings practice. Methods We collected the patients data with vancomycin concentration monitoring from 2011~2013. Based on the characteristics of these patients, we divided the samples into three groups: no-target group (concentration <10 μg·mL-1), target group (10~20 μg·mL-1), over-target group (>20 μg·mL-1). Results The proportion of dose increase in the no-target group was 3%(3/35).The ratio of no dose adjustment in target group was 91%(48/53), but the ratio of dose reduction in over-target group accounts for 12.5% (3/24). Conclusion There was no statistics difference in three group. The clinicians seem to adopt pharmacist intervention in target group. Clinical pharmacists should cooperate with clinicians to ensure effective medication usage.

Key words: vancomycin, intervention, clinical pharmacist

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