中国药物警戒 ›› 2015, Vol. 12 ›› Issue (3): 140-143.

• 基础与临床研究 • 上一篇    下一篇

夏枯草对痤疮患者唾液中IL-1α、IL-4、IL-8和TNF-α表达的影响

赵俊茹1,汪文玉2,左付国2,李小茜1,胡冬裴1*   

  1. 1上海中医药大学，上海 200120;
    2同济大学附属东方医院医院，上海 200120
  • 收稿日期:2015-01-07 出版日期:2015-03-08 发布日期:2015-07-28
  • 通讯作者: 胡冬裴，女，教授?硕导，中医基础理论。
  • 作者简介:赵俊茹，女，在读硕士，中医基础理论。

Effects of Prunella vulgaris L. on Expressions of IL-1α,IL-4,IL-8 and TNF-α in Saliva of Patients with Acne

ZHAO Jun-ru1,WANG Wen-yu2,ZUO Fu-guo2,LI Xiao-qian1,HU Dong-pei1*   

  1. 1Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China;
    2Dongfang Hospital Affiliated to Tongji University, Shanghai 200120, China
  • Received:2015-01-07 Online:2015-03-08 Published:2015-07-28

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摘要： 目的 检测夏枯草对中、重度痤疮患者唾液中白细胞介素1α（interleukin-1α, IL-1α）、白细胞介素4（interleukin-4, IL-4）、白细胞介素8（interleukin-8, IL-8）和肿瘤坏死因子-α(tumor necrosis factor-α, TNF-α)表达的影响。方法 对 100例中、重度痤疮患者口服夏枯草水煎液治疗，其中Ⅱ级38例，Ⅲ级27例，Ⅳ级35例，每人每日15 g，连续1周。采集非刺激性全唾液，运用酶联免疫吸附法（enzyme-linked immunosorbent assay，ELISA）分别检测患者治疗前后及40名正常对照者唾液中IL-1α、IL-4、IL-8和TNF-α的表达水平。结果 痤疮患者唾液中IL-1α、IL-4、IL-8和TNF-α水平较对照组有不同程度的升高，其变化程度均为Ⅳ级＞Ⅲ级＞Ⅱ级，治疗后IL-1α、IL-4、IL-8 和TNF-α水平较治疗前明显降低。结论 痤疮的发病与唾液中IL-1α、IL-4、IL-8和TNF-α水平的表达密切相关，说明免疫因素是导致痤疮发生发展的重要环节，夏枯草可能通过调节痤疮患者外周免疫因素起到治疗痤疮的作用。

关键词: 夏枯草, 痤疮, 唾液, 白细胞介素-1α, 白细胞介素-4, 白细胞介素-8, 肿瘤坏死因子-α

Abstract: Objective To detect effects of Prunella vulgaris L. on expressions of IL-1α、IL-4、IL-8 and TNF-α in saliva of patients with acne. Methods 100 patients with severe acne were treated with water extract of Prunella vulgaris L. for a week, 15 g·d-1 each person, including 38Ⅱlevel patients, 27 Ⅲ level patients, 35 Ⅳ level patients. 40 cases of normal people were selected as control. The levels of IL-1α, IL-4, IL-8 and TNF-α were respectively measured before and after treatment by ELISA kits. Results Compared with the control group, the levels of IL-1α, IL-4, IL-8 and TNF-α had different degree of rise. The variability of the population were all Ⅳ level＞Ⅲ level＞Ⅱ level. The levels of IL-1α, IL-4, IL-8 and TNF-α were significantly decreased. Conclusion The onset of acne was closely related with the expression of IL-1α, IL-4, IL-8 and TNF-α in saliva, illustrating the immune factors played important roles in the onset and development of acne. Further study of the pathogenesis of acne immune mechanism has a guiding significance for clinical diagnosis and therapy, Prunella vulgaris L. may be effective for acne by adjusting peripheral immune factors in patlents with acne.

Key words: Prunella vulgaris L., acne, saliva, IL-1α, IL-4, IL-8, TNF-α

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