自拟葛车饮治疗婴幼儿轮状病毒肠炎的临床观察

中国药物警戒 ›› 2015, Vol. 12 ›› Issue (10): 586-589.

自拟葛车饮治疗婴幼儿轮状病毒肠炎的临床观察

何春林¹, 刘国泰², 张建¹

1.南城县人民医院，江西抚州 344700;
2.抚州市第一人民医院，江西抚州 3440000

收稿日期:2015-06-30 修回日期:2015-12-07 出版日期:2015-10-08 发布日期:2015-12-07
作者简介:何春林，男，本科，主任医师，儿科消化系统疾病研究。

Clinical Observation of Self-made Geche Decoction for Treating Infantile Rotavirus Enteritis

HE Chun-lin¹, LIU Guo-tai², ZHANG Jian¹

1.Nancheng People's Hospital, Jiangxi Fuzhou 344700, China;
2.First People's Hospital of Fuzhou, Jiangxi Fuzhou 344000

Received:2015-06-30 Revised:2015-12-07 Online:2015-10-08 Published:2015-12-07

摘要/Abstract

摘要： 目的观察自拟葛车饮治疗婴幼儿轮状病毒肠炎的临床疗效。方法 90例患儿随机分为常规用药组(甲组)，利巴韦林组(乙组)和葛车饮组(丙组)，每组30例。甲组口服葡萄糖酸锌片和口服补液盐Ⅲ;乙组在甲组的基础上加静脉滴注利巴韦林;丙组在甲组的基础上加口服葛车饮，均用7天。结果治疗后，丙组的总有效率为90.0%，乙组为60.0%，甲组为63.3%，总有效率丙组与甲、乙两组比较，差异均有统计学意义(P <0.05);治疗7天后，丙组轮状病毒转阴率为83.3%，乙组为56.7%，甲组为43.3%，转阴率丙组与甲、乙两组比较，差异均有统计学意义(P <0.05)。结论葛车饮能有效缓解轮状病毒肠炎患儿临床症状及体征，加快轮状病毒的转阴，是中医药治疗该病的一种有效药物。

关键词: 中医中药, 葛车饮, 轮状病毒, 肠炎

Abstract: Objective To observe the clinical effect of self-made Geche decoction for the treatment of infantile rotavirus enteritis (IRE). Methods All 90 patients are randomly divided into three groups, Routine medication group (group A), ribavirin group (group B) and Geche decoction group (group C), 30 cases in each group. Group A was given zinc gluconate tablets and oral rehydration salts Ⅲ (ORS Ⅲ) everyday. Group B was based on group A to plus ribavirin injection. Group C was based on group A to plus Geche decoction. All of the groups were given 7 days treatment. Results The total effective rate was 63.3% in group A, 60.0% in group B and 90.0% in group C, respectively, showing significant difference (P<0.05) in comparing group C with group A and B. After 6 days of treatment, the negative conversion rate of rotavirus was 43.3% in group A, 56.7% in hroup B and 83.3% in group C, respectively, which was higher in group A than group A and B(P <0.05). Conclusion Self-made Geche decoction could effectively alleviate the clinical symptoms and signs in IRE patients, accelerate the negative conversion of rotavirus. So it is an effective drug for IRE in treatment TCM.

Key words: Traditional Chinese Medicine and Traditional Chinese Herb, Geche decoction, rotavirus, enteritis

中图分类号:

R932

何春林, 刘国泰, 张建. 自拟葛车饮治疗婴幼儿轮状病毒肠炎的临床观察[J]. 中国药物警戒, 2015, 12(10): 586-589.

HE Chun-lin, LIU Guo-tai, ZHANG Jian. Clinical Observation of Self-made Geche Decoction for Treating Infantile Rotavirus Enteritis[J]. Chinese Journal of Pharmacovigilance, 2015, 12(10): 586-589.

参考文献

[1] 叶礼燕,陈凤钦. 腹泻病诊断治疗指南[J]. 实用儿科临床杂志,2009,24(19):1538-1540.
[2] 中华人民共和国卫生部. 中国腹泻病诊断治疗方案[J]. 中国实用儿科杂志, 1998, 13 (6) :381-384.
[3] 全国腹泻病防治学术研讨会. 腹泻病疗效判断标准的补充建议[J]. 中国实用儿科杂志, 1998,13(6):384.
[4] 郑筱萸. 中药新药临床研究指导原则(试行)[M]. 北京:中国医药科技出版社,2002:139-140.
[5] 中华医学会儿科学分会消化学组,中华医学会儿科学分会感染学组,《中华儿科杂志》编辑委员会，等. 儿童腹泻病诊断治疗原则的专家共识[J]. 中华儿科杂志,2009,47(8):634-636.
[6] 黄婉英. 喜炎平治疗小儿轮状病毒腹泻178例[J]. 医药导报,2009,
28(5):596-598.
[7] 吴瑛,陈万强,金玉,等. 轮泻停敷脐辅助治疗小儿轮状病毒肠炎的临床观察[J]. 中国中西医结合杂志,2010,30(12):1275-1278.
[8] 尹东奇,韩新民,刘奔,等. 苍葛止泻灵抗轮状病毒模型的实验研究[J]. 湖北中医药大学学报,2012,14(6):15-17.
[9] 李道坤,冯娇梅,李玉萍,等. 腹泻Ⅰ号方治疗小儿轮状病毒性腹泻60例[J]. 中国实验方剂学杂志,2013,19(15):302-305.
[10] 董峥,张素兰,孙亚锋,等. 中药贴敷神阙穴联合锌剂治疗轮状病毒肠炎的疗效观察[J]. 浙江中医杂志,2013,48(4):264.
[11] 沙向红,朱惠平,陈怀. 加味葛根芩连汤治疗急性小儿湿热型秋季腹泻临床观察[J]. 现代中西医结合杂志,2006,15(16):2185-2186.
[12] 赵亚岚. 苍苓葛根汤治疗小儿秋季腹泻120例疗效观察[J]. 新中医,2007,39(9):40-41.
[13] 王本祥. 现代中药药理与临床[M]. 天津:天津科技翻译出版社,2004:525-1700.
[14] 郑皓,王晓静. 葛根的药理作用研究概况[J]. 光明中医,2006,21(3):49-51.
[15] 汤新慧. 白术多糖对小鼠免疫功能的影响[J]. 中医研究,1998,
11(2):7.