中国药物警戒 ›› 2014, Vol. 11 ›› Issue (5): 268-270.

• 质量与工艺研究 • 上一篇    下一篇

经舒宁颗粒的提取和醇沉工艺优选

焦玉1, 2, 王兵娥1, 黄德红1, 万宏1, 王洪军1, 李青3, 李朝霞3, 胡思荣3*   

  1. 1湖北中医药大学附属襄阳医院药学部,湖北 襄阳 441000;
    2襄阳市中医医院胡思荣工作室,湖北 襄阳 441000;
    3襄阳市中医医院科教科,湖北 襄阳 441000
  • 收稿日期:2016-02-03 修回日期:2016-02-03 出版日期:2014-05-08 发布日期:2016-03-02
  • 作者简介:焦玉,女,硕士,药师,医院新制剂研究和药品检验。
  • 基金资助:
    襄阳市科技计划项目资助,襄科业[2012]42号

Study on Extraction Process and Alcohol Precipitation of Jingshuning Granules

JIAO Yu1, 2, WANG Bing-e1, HUANG De-hong1, WAN Hong1, WANG Hong-jun1, LI Qing, HU Si-rong2   

  1. 1Pharmacy Department, Xiangyang Hospital Affiliated to Hubei University of Chinese Medicine, Hubei Xiangyang 441000, China;
    2HU Si-rong Studio, Xiangyang Hospital of Traditional Chinese Medicine,Hubei Xiangyang 441000, China;
    3Department of Research and Teaching, Xiangyang Hospital of Traditional Chinese Medicine, Hubei Xiangyang 441000, China
  • Received:2016-02-03 Revised:2016-02-03 Online:2014-05-08 Published:2016-03-02

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摘要： 目的优选经舒宁颗粒的提取和醇沉工艺。方法采用正交试验法,对提取和醇沉的各主要影响因素进行考察,以芍药苷的提取率和浸膏得率为指标,考察加水倍量、提取时间和次数;以醇沉后的芍药苷含量和干膏得率为指标,考察醇沉药液相对密度、乙醇浓度和静置时间。结果优选的最佳提取工艺为加水10倍量,提取3次,每次2h;最佳醇沉工艺为醇沉药液相对密度1.12,乙醇浓度60%,醇沉时间24h。结论优选出的提取和醇沉工艺合理可行,稳定可靠,适合工业化生产。

关键词: 经舒宁颗粒, 提取和醇沉工艺, 正交试验, 芍药苷

Abstract: Objective To optimize the process of extraction and alcohol precipitation of Jingshuning Granules. Methods Using orthogonal test, the main influence factors of extraction and alcohol precipitation were investigated. Water volume, extraction time and times were inspected, with the metastasis rate of paeoniflorin and extract yield as influencing factors. The content of paeoniflorin and dry extract yield were used as index to study the relative density of concentrated liquid, alcohol concentration and time. Results The optimized extraction process was to add 10 times amount of water, extract for 3 times, 2 hours each time.The best process of alcohol precipitation was that the relative density of concentrated liquid was 1.12, alcohol concentration was 60%, and alcohol precipitation time was 24 hours. Conclusion The optimized technology of extraction and alcohol precipitation was reasonable, stable and reliable. It is suitable for industrial production.

Key words: Jingshuning Granules, process of extraction and alcohol precipitation, orthogonal test, paeoniflorin

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