中国药物警戒 ›› 2014, Vol. 11 ›› Issue (5): 261-263.

• 基础研究 • 上一篇    下一篇

辛夷脂素的提取分离及其抗过敏作用研究

胡瀚文1, 徐新刚2, 张学顺3*, *, 孙蓉2   

  1. 1山东中医药大学,山东 济南 250355;
    2山东省中医药研究院,山东 济南,250014;
    3山东中医药大学第一附属医院,山东 济南 250011
  • 收稿日期:2016-02-03 修回日期:2016-02-03 出版日期:2014-05-08 发布日期:2016-03-02
  • 作者简介:胡瀚文,女,在读硕士,药物新剂型与新技术。
  • 基金资助:
    山东省科技攻关课题,辛夷抗过敏性鼻炎的实验与临床研究[（1997）年第971226313号]

Research of Extraction and Separation Technology and Anti-allergic Effect about Forgesin

HU Han-wen1, XU Xin-gang2, ZHANG Xue-shun3, *, SUN Rong2   

  1. 1Shandong University of Traditional Chinese Medicine, Shandong Ji'nan 250355, China;
    2Shandong Academy of Chinese Medicine, Shandong Ji'nan 250014, China;
    3First Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong Ji'nan 250011, China
  • Received:2016-02-03 Revised:2016-02-03 Online:2014-05-08 Published:2016-03-02

PDF (PC)

159

摘要： 目的探索辛夷药材中辛夷脂素的分离精制工艺,进行辛夷脂素的抗过敏作用的实验研究。方法分析鉴定从辛夷中提取的单体成分结构。观察单体成分对抗过敏性毛细血管通透性增强实验和对小鼠皮肤被动过敏反应的作用。结果经过UV、IR、MS、13C-NMR确定了此单体成分的结构,证实为辛夷脂素。辛夷脂素对抗过敏性毛细血管通透性增强和对小鼠皮肤被动过敏反应有效。结论辛夷脂素是辛夷的主要活性成分之一,具有抗过敏性毛细血管通透性增强的作用和抗小鼠皮肤被动过敏反应的作用,并呈现一定的剂量依赖关系。

关键词: 辛夷脂素, 有效成分, 抗过敏作用

Abstract: ObjectiveTo explore purification conditions of fargesin in Magnolia and conduct its experimental study of anti-allergic effect. MethodsThe structure of monomer composition from Magnolia was analyzed and identified. The effects on the experiments of anti-permeability strengthening of allergenic capillary vessels and passive anaphylaxis of the skin on mice from the monomer composition were explored. ResultsThe monomer composition was confirmed to be fargesin by UV, IR, MS and 13C-NMR. And it was considered to be effective to the effects on the experiments of anti-permeability strengthening of allergenic capillary vessels and passive anaphylaxis of the skin on mice. ConclusionFargesin, as one of the most effective components, presents a certain dose-efficacy relationship in the terms of the effects on the experiments of anti-permeability strengthening of allergenic capillary vessels and passive anaphylaxis of the skin on mice.

Key words: fargesin, effective component, anti-allergic effect

中图分类号: