中国药物警戒 ›› 2012, Vol. 9 ›› Issue (6): 333-334.

• 基于“功效”的有毒中药毒性综合评价 • 上一篇    下一篇

香加皮不同组分发挥镇痛作用的安全范围研究

朱兰兰1，2，鲍志烨3，王会3，黄伟2，孙蓉2，*   

  1. 1 天津中医药大学，天津 300193；
    2 山东省中医药研究院，山东 济南 250014；
    3 山东中医药大学，山东 济南 250355
  • 收稿日期:2012-05-11 出版日期:2012-06-10 发布日期:2015-08-10
  • 通讯作者: 孙蓉,女,研究员,博导,博士,中药药理与毒理。E-mail：sunrong107@163.com
  • 作者简介:朱兰兰，女，硕士研究生，中药分析与毒代研究。
  • 基金资助:
    国家重点基础研究发展计划 （973）中医基础理论专项资助项目（2009CB522802）

The Analgesic Effect Study on Margin of Safety on Different Components from Cortex Periplocae

ZHU Lan-lan1, 2, BAO Zhi-ye3, WANG Hui2, HUANG Wei3, SUN Rong2, *   

  1. 1 Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;
    2 Shandong Research Academy of TCM, Shandong Jinan 250014, China;
    3 Shandong University of Traditional Chinese Medicine,Shandong Jinan 250355, China
  • Received:2012-05-11 Online:2012-06-10 Published:2015-08-10

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摘要： 目的研究香加皮不同组分发挥镇痛作用的安全范围。方法用热板法观察香加皮不同组分镇痛作用，依据本实验室前文报道的香加皮不同组分急性毒性研究结果，用Bliss法分别计算各组分发挥镇痛药效的ED50、ED95、和急性毒性的LD50，LD5，求得香加皮不同组分发挥镇痛作用的治疗指数（TI），安全系数（SF），以此评价其发挥镇痛作用的安全范围。结果香加皮不同组分均有明显的镇痛作用，呈现明显的量效关系，不同组分发挥镇痛作用的安全范围有所不同，香加皮水提提组分ED50=1.5698 g·kg-1·d-1，TI=59.611，SF=17.4702，其ED95和LD5分别相当于药典规定的人日用量的48.0和839.0倍。香加皮醇提组分ED50=1.3687 g·kg-1·d-1，TI=44.853，SF=14.2405，其ED95和LD5分别相当于药典规定的人日用量的35.7和509.0倍。结论香加皮水提组分发挥镇痛作用的安全范围大于醇提组分，在应用香加皮醇提组分时更应密切注意不良反应的发生并加强用药监测。

关键词: 香加皮, 镇痛, 安全范围, 治疗指数, 安全系数

Abstract: Objective To research analgesic effect of the margin of safety of Cortex Periplocae. MethodsAnalgesic effect from different components from Cortex Periplocae were investigated by hot plate test; the symptoms in mice were observed, the experimental datas of ED50, ED95, LD50 and LD5 are calculated by the Bliss method and the therapeutic index(TI), safety factor(SF) of different components from Cortex Periplocae were assured by applying some formulas. ResultsThe different components from Cortex Periplocae showed good effect of analgesia, and showed certain dose-effect relationship, ED50 of the water extracts from Cortex Periplocae is 1.5698 g·kg-1·d-1, TI is 59.611 and SF is 17.4702, ED95 is equal to 48.0 times and LD5 is equal to 839.0 times of 70kg people's daily dried medicinal herb expenses. The alcohol extracts from Cortex Periplocae of ED50 is 1.3687 g·kg-1·d-1, TI is 44.853 and SF is 14.2405, ED95 is equal to 35.7 times and LD5 is equal to 509.0 times of 70kg people's daily dried medicinal herb expenses. ConclusionThe analgesic effect of the margin of safety from water extracts is greater than the alcohol extracts from Cortex Periplocae. We should pay more attention to the occurrence of adverse reactions in the application.

Key words: Cortex Periplocae, analgesia, the margin of safety, therapeutic index, safety factor