中国药物警戒 ›› 2012, Vol. 9 ›› Issue (5): 306-308.

• 药品不良反应监测 • 上一篇    下一篇

15例银杏达莫注射液致严重药品不良反应文献分析

金锋1，王雅丽2，兰姗3，杨乐2，*   

  1. 1 吉林省食品药品评价中心，吉林 长春 130062；
    2 国家食品药品监督管理局药品评价中心，北京 100045；
    3 四川省药品不良反应监测中心，四川 成都 610017
  • 收稿日期:2012-03-20 出版日期:2012-05-10 发布日期:2015-08-10
  • 通讯作者: 杨乐,男,主管药师,药品不良反应监测与评价。E-mail：yangle@cdr.gov.cn
  • 作者简介:金锋，男，主管药师，药品不良反应与医疗器械不良事件监测。

Literature Analysis of 15 Cases of Serious Adverse Drug Reaction by Ginkgo Leaf Extract and Dipyridamole Injection

JIN Feng1, WANG Ya-li2, LAN Shan3, Yang Le2, *   

  1. 1Jilin Center for Drug Reevaluation, Jilin Changchun 130062, China;
    2 Center for Drug Reevaluation, SFDA, Beijing 100045, China;
    3 Center for ADR monitoring of Sichuan, Sichuan Chengdu 610017, China
  • Received:2012-03-20 Online:2012-05-10 Published:2015-08-10

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摘要： 目的通过对15例银杏达莫注射液致严重药品不良反应的文献进行分析，探讨其引起严重不良反应的规律和原因，为临床合理用药提供参考。方法对1995~2012年中国期刊全文数据库文献进行检索，对其中涉及银杏达莫注射液致严重药品不良反应的14篇文献中报道的15例病例报告进行统计与分析。结果与结论 银杏达莫注射液致严重不良反应与剂量有关，多为速发型反应，过敏性休克患者的比例较高，严重程度高，临床应用应加强监测，密切防范不良反应的发生。

关键词: 银杏达莫注射液, 严重药品不良反应, 文献分析

Abstract: Objective Through analysing 15 Serious ADR cases of the Ginkgo Leaf Extract and Dipyridamole Injection to explore the rules and causes of adverse reactions, provide a reference for clinical rational use of drugs. MethodsBy searching literature from 1995~2012 Chinese journal full-text database, 14 Serious ADR literatures of Ginkgo Leaf Extract and Dipyridamole Injection involving 15 cases, were Statistically analyzed. Resultsand ConclusionGinkgo leaf extract and dipyridamole injection induced serious ADR associated with dose. Ginkgo Leaf Extract and Dipyridamole Injection-related adverse reaction, anaphylactic shock, a higher proportion of patients occurred a short time, serious high degree of clinical care should be strengthened and close to prevent the occurrence of adverse reactions.

Key words: Ginkgo Leaf Extract and Dipyridamole injection, serious adverse drug reaction, literature analysis