羟苯酯类防腐剂的不良反应

中国药物警戒 ›› 2012, Vol. 9 ›› Issue (5): 303-305.

羟苯酯类防腐剂的不良反应

李中东，张云轩，郭燕萍，施孝金，钟明康

复旦大学附属华山医院药剂科，上海 200040

收稿日期:2011-08-29 出版日期:2012-05-10 发布日期:2015-08-10
作者简介:李中东，男，博士，副主任药师，新药药动学与临床药学。

Adverse Drug Reactions Induced by Parabens Used as Preservatives

LI Zhong-dong, ZHANG Yun-xuan, GUO Yan-ping, SHI Xiao-jin, ZHONG Ming-kang

Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai 200040, China

Received:2011-08-29 Online:2012-05-10 Published:2015-08-10

摘要/Abstract

摘要： 目的综述羟苯酯类防腐剂不良反应。方法参阅国外相关文献，总结羟苯酯类的不良反应。结果羟苯酯类是最常用的防腐剂，不良反应表现为过敏、交叉反应和激素效应，会发生“羟苯酯类悖论”现象。结论医务人员使用含羟苯酯类的制剂处方时，要重视它的不良反应，做到合理运用。

关键词: 羟苯酯类, 过敏反应, 交叉反应, 羟苯酯类悖论, 激素效应

Abstract: Objective To review the adverse drug reactions induced by parabens when used as preservatives. MethodsA simple conclusion on adverse drug reactions induced by parabens was carried out by reviewing the related references. ResultsParabens are the most commonly used preservatives. Parabens are likely to cause adverse reactions as allergic reactions, cross reactions and estrogenic activity, paraben paradox can also be observed. ConclusionProfessional clinicians must pay high attention to the adverse reactions of parabens contained in the pharmaceutical products and use them rationally as possible as they can.

Key words: parabens, allergic reaction, cross reaction, paraben paradox, estrogenic activity

李中东，张云轩，郭燕萍，施孝金，钟明康. 羟苯酯类防腐剂的不良反应[J]. 中国药物警戒, 2012, 9(5): 303-305.

LI Zhong-dong, ZHANG Yun-xuan, GUO Yan-ping, SHI Xiao-jin, ZHONG Ming-kang. Adverse Drug Reactions Induced by Parabens Used as Preservatives[J]. Chinese Journal of Pharmacovigilance, 2012, 9(5): 303-305.

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