中国药物警戒 ›› 2012, Vol. 9 ›› Issue (2): 110-113.

• 药品不良反应监测 • 上一篇    下一篇

格列苯脲低血糖反应致死亡37例文献分析

马满玲，郭美华，杨丽杰   

  1. 哈尔滨医科大学附属第一医院药学部，黑龙江 哈尔滨 150001
  • 收稿日期:2011-07-28 出版日期:2012-02-10 发布日期:2015-08-10
  • 作者简介:马满玲， 女，主任药师，硕士生导师，临床药学及药理学。

Literature Analysis of the Hypoglycemia Deaths Caused By Glibenclamide

MA Man-ling, GUO Mei-hua, YANG Li-jie   

  1. Department of Pharmacy, The First Affiliated Hospital of Harbin Medical University, Heilongjiang Harbin 150001, China
  • Received:2011-07-28 Online:2012-02-10 Published:2015-08-10

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摘要： 目的调查格列苯脲低血糖反应致死亡病例的情况并分析相关因素，为临床合理用药提供参考。方法对37例格列苯脲低血糖反应致死亡病例进行分类统计与分析。结果男女比例为1.6:1，87.8%的病例为老年人（>60岁），86.5%的病例不规范用药，8.1%单独用药，75.7%联合用药，100%的病例临床表现均为不同程度的低血糖昏迷，54.1%的病例因发现不及时、误诊、漏诊等原因而延误治疗、抢救时机。死亡的原因是多方面的，56.8%的病例因长时间低血糖昏迷造成多器官衰竭或呼吸、循环衰竭而死亡。结论格列苯脲低血糖昏迷危害极大，要重视降糖药物安全性。使用时须慎重考虑年龄、用法用量等相关因素，做到合理用药，做到早诊断，早治疗，以减少格列苯脲低血糖反应及其严重后果的发生。

关键词: 格列苯脲, 低血糖反应, 死亡, 合理用药

Abstract: Objective To survey the cases of hypoglycemia deaths caused by glibenclamide and analyze the relevant factors, provide a reference for the clinical use of drugs. Methods37 cases of glibenclamide-induced hypoglycemia deaths were statistically analyzed. ResultsMale to female ratio was 1.6:1,87.8% of cases for the elderly(>60), 86.5% of the patients had non-standard situation of drug use, 8.1% single drug, 75.7% of cases combined use of drugs, 100% of the cases are different degrees of clinical symptoms of low blood sugar coma, 54.1% of the cases were not discovered in time, misdiagnosed or missed. There are many reasons of death, 56.8% of death cases are caused by prolonged hypoglycemic coma with multiple organ failure or respiratory, circulatory failure. ConclusionHypoglycemic coma caused by glibenclamide can cause great harm. Hypoglycemic drugs should pay attention to safety. When we use this drug, we must carefully consider the age, usage, dosage and other relevant factors, then make rational use of drugs to reduce the incidence of low blood sugar reactions.

Key words: glibenclamide, drug-induced hypoglycemia, death, rational drug use