中国药物警戒 ›› 2011, Vol. 8 ›› Issue (3): 180-181.

• 药品不良反应监测 • 上一篇    下一篇

160例抗精神病药物不良反应/事件分析

张郦, 钱秋红, 宋建宏, 费玥, 凌燕虹   

  1. 上海市长宁区精神卫生中心,上海 200335
  • 收稿日期:2015-08-27 修回日期:2015-08-27 出版日期:2011-03-10 发布日期:2015-08-27
  • 作者简介:张郦,女,副主任医师,精神医学。

Analysis of 160 Cases Of Adverse Drug Reaction/Event of Used Anti-Neurosis Medicine with Inpatients

ZHANG Li, QIAN Qiu-hong, SONG Jian-hong, FEI Yue, LING Yan-hong   

  1. Shanghai Changning Mental Health Center, Shanghai 200335, China
  • Received:2015-08-27 Revised:2015-08-27 Online:2011-03-10 Published:2015-08-27

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摘要： 目的 探讨抗精神病药物所致不良反应/事件（ADR/ADE）的发生情况,为临床合理用药提供参考。方法 对我院2007年1月至2010年3月住院患者中,搜集上报的160例抗精神病药物所致不良反应/事件,对患者性别、年龄、用法用量、合并用药、不良反应/事件史以及表现等情况进行统计分析。结果 本院上报的抗精神病药物发生的不良反应/事件主要发生在30~60岁;不良反应/事件共累及7个系统-器官,主要为中枢神经系统损害和肝功能损害;引起不良反应/事件的药物中,非典型抗精神病药物的上报例数多于典型抗精神病药物。结论 医疗机构应重视抗精神病药引起的不良反应,加强抗精神病药的合理应用。

关键词: 抗精神病药, 神经系统, 药品不良反应/事件

Abstract: Objective To investigate the antipsychotic-induced adverse drug reaction/event(ADR/ADE), and provide advice for the rational use of drugs. Methods To conduct a statistical analysis based upon the information from 160- inpatients with ADR/ADE which were reported from January 2007 to March 2010 in my hospital such as gender, age, dosage regimen, drug combination, etc. Results ADR/ADE is likely to be reported in various ages section during inpatients, particularly those are 30~60 years old. It involves seven systems, will mainly cause the central nervous system damage and hepatic dysfunction. Among those drug reported to have adverse reaction, there are more atypical antipsychotics reported than typical antipsychotics. Conclusion Medical institutions should pay attention to antipsychotic-induced adverse reactions and rational use of it.

Key words: antipsychotic drug, nervous system, adverse drug reaction/event(ADR/ADE)

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