中国药物警戒 ›› 2011, Vol. 8 ›› Issue (1): 52-56.

• 药品不良反应监测 • 上一篇    下一篇

94例疑似药品不良反应死亡病例报告分析

吕小琴, 陈志根   

  1. 浙江省药品不良反应监测中心,浙江 杭州 310012
  • 收稿日期:2010-08-30 出版日期:2011-01-10 发布日期:2015-08-24
  • 作者简介:吕小琴,女,主管药师,药理学。

Analysis of 94 Cases of Suspected Death Caused by Drugs

LV Xiao-qin, CHEN Zhi-gen   

  1. Zhejiang center for ADR monitoring, Zhejiang Hangzhou 310012, China
  • Received:2010-08-30 Online:2011-01-10 Published:2015-08-24

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摘要： 目的 分析药品在使用过程中可能导致患者死亡的主要特点和一般规律,为临床安全、合理用药提供参考。方法 对2008年1月至2010年6月,浙江省药品不良反应监测中心收到的94例疑似药品不良反应死亡病例报告进行统计与分析。结果 抗感染药物引起的疑似死亡病例最为多见（48.5%）,其次为中药注射剂（9.1%）;给药途径以静脉滴注所占比例最大（67.4%）;超过半数病例在用药后2小时内出现不良反应症状（64.9%）;患者死因中,因过敏样反应和过敏性休克导致死亡最为多见（48.9%）,其次为循环系统损伤、循环-呼吸系统损伤致死等。结论 抗感染药物和中药注射剂的广泛应用、静脉滴注给药方式的广泛应用和药品质量的良莠不齐是导致药品不良反应甚至死亡的主要因素,应加强其使用的监督管理。

关键词: 药品不良反应, 死亡, 报告分析, 合理用药

Abstract: ObjectiveTo investigate the features and general pattern of suspected death caused by drugs, and provide references of clinical rational and safety use of drug. MethodsA total of 94 cases collected in zhejiang center for ADR monitoring from Jan. 2008 to Jun. 2010 were analyzed retrospectively. ResultsA total of 132 drugs were involved in the 94 cases, mainly anti-infective drugs(48.5%), followed by traditional Chinese Medicine injections(9.1%). The main route of administration was by intravenously guttae(67.4%). More than half of the cases appeared symptoms of adverse reactions within 2 hours after taking drugs. Allergic-like reaction and anaphylactic shock leading to death was the most common(48.9%), followed by circulatory system damage, circulation-respiratory injury. ConclusionADR monitoring and reporting should be strengthened to ensure safe, effective and rational drug use in the clinic. The suspected death caused by drugs were mainly induced by the popular use of anti-infective drugs and traditiona Chinese Medicine injection, mainly drugs use by intravenously guttae and uneven qualities of drugs. Measures should be taken to tighten control on rational drug use.

Key words: adverse drug reaction(ADR), death, analysis of reports, rational use of drug

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