脉络宁注射液的安全性评价

中国药物警戒 ›› 2011, Vol. 8 ›› Issue (1): 46-49.

脉络宁注射液的安全性评价

陆叶^1,2, 徐露³, 徐厚明², 于浩²

1. 南京医科大学公共卫生学院,江苏南京 210029;
2. 江苏省药品不良反应监测中心, 江苏南京 210002;
3. 南京中医药大学药学院,江苏南京 210046

收稿日期:2010-08-02 出版日期:2011-01-10 发布日期:2015-08-24
通讯作者: 于浩,女,博士,硕士生导师,疾病预防与控制。E-mail：njyuhao@vip.sina.com
作者简介:陆叶,男,在读硕士研究生,药品不良反应监测、药物滥用监测。

Safety Evaluation of Mailuoning Injection

LU Ye^1,2, XU Lu³, XU Hou-ming, YU Hao²

1. School of Public Health Nanjing Medical University, Jiangsu Nanjing 210029, China;
2. Jiangsu Center for ADR Monitoring, Jiangsu Nanjing 210002, China;
3. Nanjing University of Chinese Medicine, Jiangsu Nanjing 210046, China

Received:2010-08-02 Online:2011-01-10 Published:2015-08-24

摘要/Abstract

摘要： 目的观察脉络宁注射液临床应用的不良反应发生率、发生类型以及相关危险因素,为临床安全用药提供依据。方法检索中国知网《中国期刊全文数据库》（1990~2009年）,以“脉络宁”、“不良反应”、“治疗”及“病例报道”等为关键词,下载原文。收录中国期刊网全文428篇,经筛选纳入314篇文献, 包含217篇关于不良反应发生率和97篇不良反应发生类型的文献。结果脉络宁注射液不良反应的总发生率为1.898%,发生类型有全身性损害,皮肤及其附件损害,胃肠系统损害,呼吸系统损害,心血管外损害,中枢及外周神经系统损害等,其中全身性损害构成比为20.93%,呼吸系统损害构成比为20.06%。70.24%的患者都是循环系统疾病,发生时间集中在用药后10分钟内,且60岁上的老年人发生不良反应较多。结论加强脉络宁注射液不良反应监测,完善药品说明书内容和临床医务人员的合理用药,防止其严重不良反应的发生。

关键词: 脉络宁, 不良反应, 治疗, 病例报道

Abstract: ObjectiveIn order to provide the basis for clinical drug safety, observed the adverse reaction incidences, types, proportions and risk factors of Mailuoning injection. MethodsUsing "mailuoning","adverse reaction","treat","case report", etc. as the key words, original case reports were downloaded from Chinese Journal Full-text Database(1990 ~2009) in CNKI. Picked out 314 literatures from the whole 428 results, including 217 pieces of adverse reaction incidences and 97 pieces of adverse reaction types. ResultsThe incidence of adverse events occurred to 1.898%, the type of systemic skin damage, categories, gastrointestinal system and its attachments, damage, the respiratory system, cardiovascular central and peripheral nervous system etc, which constitute systemic damage than for 20.93%, respiratory damage than for 20.06% form. 70.24% patients were circulatory disease, time focused on after 10 minutes, and 60 people on an adverse reactions. ConclusionBy intensively warded the suffers and perfecting the content of the drug manual and the clinician's rational drug use,to avoid occurrence of serious adverse reactions.

Key words: Key wdrds: mailuoning, adverse drug reaction(ADR), treat, case report

中图分类号:

R283.6

陆叶, 徐露, 徐厚明, 于浩. 脉络宁注射液的安全性评价[J]. 中国药物警戒, 2011, 8(1): 46-49.

LU Ye, XU Lu, XU Hou-ming, YU Hao. Safety Evaluation of Mailuoning Injection[J]. Chinese Journal of Pharmacovigilance, 2011, 8(1): 46-49.

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