中国药物警戒 ›› 2010, Vol. 7 ›› Issue (10): 588-591.

• 基础及临床研究 • 上一篇    下一篇

HIV暴露婴儿预防接种免疫效果报告

桂秀芝1, 翁毓秋2, 莫胜1, 邱慧1   

  1. 1.柳州市妇幼保健院,广西柳州,545001；
    2.柳州市疾病预防控制中心,广西柳州,545001
  • 收稿日期:2010-07-21 修回日期:2016-03-12 出版日期:2010-10-08 发布日期:2016-03-09
  • 作者简介:桂秀芝,女,主任医师,传染病监测及预防控制。
  • 基金资助:
    2008 年度广西医疗卫生计划课题,立项文件：广西卫生厅桂卫科教[2008] 25 号；合同号：Z2008344

Report on Vaccine-induced Immunity of HIV-exposed Infants

GUI Xiu-zhi1, WENG Yu-qiu2, MO Sheng1 ,QIU Hui1   

  1. 1..Liuzhou Women and Children Health Hospital, Guangxi Liuzhou 5450012, China;
    2..Liuzhou CDC, Guangxi Liuzhou 545001, China
  • Received:2010-07-21 Revised:2016-03-12 Online:2010-10-08 Published:2016-03-09

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摘要： 目的为评估经HIV 母婴阻断措施后该类婴儿群对卡介苗、乙肝疫苗的免疫反应能力,为相关部门制定此类婴儿的预防接种政策提供依据。方法为HIV 感染孕妇提供综合性母婴阻断措施,将其婴儿设为观察组,母亲HIV阴性婴儿为对照组。对2 组婴儿按常规进行预防接种,在接种卡介苗3~6 个月后作结核菌素（PPD）试验、乙肝疫苗7~10个月后作乙肝抗体（抗-HBs）水平检测。结果HIV感染孕妇经孕期规范抗病毒治疗后母婴阻断效果明显,其婴儿感染率远低于未治疗者。2 组婴儿的PPD 阳性率及卡痕阳性率均达90%以上；抗-HBs 水平,观察组为296.83±3.10 mIU/mL,对照组为354.30±2.37mIU/mL。结论本组资料显示,HIV 阳性孕妇经综合性HIV母婴阻断措施后其所娩婴儿对乙肝疫苗和卡介苗具有类似于普通婴儿的免疫反应能力。

关键词: HIV暴露婴儿, 预防接种, 免疫效果

Abstract: The purpose is to investigate immune tolerance and the efficacy of hepatitis B vaccine and BCG immunization of infants on the prevention of mother to child transmission(PMTCT) programs, in order to provide the basis for corresponding vaccination policy. We provide PMTCT service to HIV -positive mothers and define infants of HIV-positive mothers as experimental group(EG), while infants beard by HIV-negative mothers as comparative group (CG). The two groups were vaccinated regularly and had PPD tests and anti-HBs level tests. In consequence, the HIV prevalence in infants born to mothers on the PMTCT programs is substantially lower than infants not in the program.The PPD-positive rates of the both groups are above 90%, and the mean content of anti-HBs for EG and CG are 296.83~3.10mIU/mL and 354.30~2.37mIU/mL respectively. In Conclusion , the efficacy of hepatitis B and BCG vaccine immunization of infants born to HIV-positive mothers is similar to normal infants.

Key words: HIV-exposed infants, vaccination, immunity effect

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