中国药物警戒 ›› 2010, Vol. 7 ›› Issue (1): 55-58.

• 药品不良反应监测 • 上一篇    下一篇

59例生脉注射液不良反应文献分析

张文霞, 钟希文, 曾聪彦*   

  1. 广州中医药大学附属中山市中医院药学部,广东 中山 528400
  • 收稿日期:2016-02-18 修回日期:2016-02-18 出版日期:2010-01-08 发布日期:2016-02-18
  • 通讯作者: *通讯作者：曾聪彦,男,副主任中药师,医院药学研究。E-mail:zszcy@126.com
  • 作者简介:张文霞,女,在读硕士研究生,广东地产药材研究与开发。
  • 基金资助:
    中山市科技计划资助项目（20091A028）

Literature Analysis of 59 Adverse Drug Reaction Reports of Shengmai Injection

ZHANG Wen-xia, ZHONG Xi-wen, ZENG Cong-yan*   

  1. Zhongshan Hospital, Guangzhou University of TCM,Guangdong Zhongshan 528400, China
  • Received:2016-02-18 Revised:2016-02-18 Online:2010-01-08 Published:2016-02-18

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摘要： 目的 探讨生脉注射液不良反应发生的一般规律特点,为临床合理用药提供参考。方法 对1994~2008年医药学期刊报道有关生脉注射液致不良反应文献进行整理和分析。结果 生脉注射液所致不良反应与年龄无关,男性略多于女性,多在用药过程中半小时内发生。不良反应累及多个系统-器官,临床表现复杂多样,主要表现为变态反应,严重者可出现过敏性休克。结论 临床医师与药师应了解生脉注射液所致不良反应的规律和特点,加强其应用的监测,以减少不良反应的发生。

关键词: 生脉注射液, 不良反应, 文献, 分析

Abstract: Objective To explore the general pattern and characteristics of adverse drug reactions(ADR) induced by Shengmai injection so as to provide references for clinical rational use of drug. Methods ADR of Shengmai Injection in 59 case, reported in domestic medical journals from 1994~2008, were collected and analyzed. Results the ADR of Shengmai injection were independent of patient's age and denpendent of patient's sex, male patient were more than female patient. The onset of ADR was usually within 30min after injection. ADR could involve in multiple organs and systems, and clinical manifestations were various, mainly were allergic reaction. Severe allergic reaction could result in anaphylactic shock. Conclusion Doctors and pharmacists should know the pattern and characteristics of ADR, and the use of Shengmai injection should be under strict monitoring to reduce the occurrence of serious ADR.

Key words: Shengmai injection, adverse drug reaction(ADR), literature, analysis

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