基于数据挖掘海藻-甘草配伍源流考证及特征分析

doi:10.19803/j.1672-8629.20250095

摘要/Abstract

摘要： 目的探讨海藻-甘草配伍的历史源流和临床应用特征,分析其安全性和有效性,为临床合理使用提供参考。方法检索建库至2025年6月20日中国知网、万方数据、维普网、古今医案云平台V2.3.9等数据库,筛选出含海藻-甘草药对的方剂,运用Microsoft Excel 2021建立相关处方数据库,从历史源流、应用主治、配伍特征等方面进行统计分析,以SPSS Modeler 18.0及SPSS Statistics 27.0进行关联规则与聚类分析和深度挖掘,归纳核心中药。结果共纳入方剂123首,涉及中药334味,总频次1 809次。海藻-甘草同用起源于唐代,主要治疗外科的乳癖、瘰疬,内科的瘿病,妇科的癥瘕,眼科的暴盲证等,其安全性与剂量、配伍比例、药物组合等密切相关,两者临床组合同用多使用生品以2∶1配伍,常与昆布、半夏、当归、陈皮、川芎等药物配伍使用。结论海藻-甘草药对临床配伍使用广泛,以含有海藻-甘草的古代经典名方与辨证论治为基础,整合海藻-甘草配伍源流与临床应用数据,可为临床安全、有效、合理运用提供参考。

关键词: 海藻, 甘草, 中药“十八反”, 源流, 配伍特征

Abstract: Objective To explore the origin and clinical applications of sargassum-glycyrrhiza medicinal pairs, and analyze their safety and efficacy. Methods We searched such databases as CNKI, Wanfang, VIP, and the Cloud Platform of Ancient and Modern Medical Cases V2.3.9 for prescriptions relating to sargassum-glycyrrhiza pairs, established a prescription database by using Microsoft Excel 2021, and analyzed such pairs statistically in terms of origin, major applications, and compatibility. The association rules and clustering were investigated in depth by using SPSS Modeler 18.0 and SPSS Statistics 27.0. Results A total of 123 formulas were included, involving 334 flavors of Chinese medicines and with a total frequency of 1 809 times. The combinations of sargassum-glycyrrhiza originated in the Tang Dynasty, and were used mostly to treat breast fetish and scrofula, gall diseases, obstruction in the abdomen, and blindness. The safety depended on the dosage, the proportion of either drug, and the combination of medicines. Clinically, raw and unprocessed products of these drugs were usually used at the ratio of 2∶1, and were often combined with such drugs as kombucha, galbanum, angelica, dried tangerine peel and Ligusticum wallichii. Conclusion Sargassum- glycyrrhiza medicinal pairs are widely used in clinical combinations. The data on their clinical applications provided in this study is expected to contribute to safe, effective and rational clinical use of related drugs.

Key words: Sargassum, Glycyrrhiza, Eighteen Antagonisms, Origin, Compatibility

中图分类号:

韦彦旭, 郑雅莉, 罗思思, 廖昭君, 张诗艺, 修琳琳. 基于数据挖掘海藻-甘草配伍源流考证及特征分析[J]. 中国药物警戒, 2026, 23(1): 50-54.

WEI Yanxu, ZHENG Yali, LUO Sisi, LIAO Zhaojun, ZHANG Shiyi, XIU Linlin. Origin and Compatibility of Sargassum-Glycyrrhiza Based on Data Mining[J]. Chinese Journal of Pharmacovigilance, 2026, 23(1): 50-54.

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