中国药物警戒 ›› 2023, Vol. 20 ›› Issue (10): 1173-1175.
DOI: 10.19803/j.1672-8629.20220442

• 安全与合理用药 • 上一篇    下一篇

1例大剂量胺碘酮诱发伊伐布雷定闪光现象的药学监护

赵瑞, 于晓佳, 安卓玲*   

  1. 首都医科大学附属北京朝阳医院药事部,北京 100020
  • 收稿日期:2022-07-26 出版日期:2023-10-15 发布日期:2023-10-16
  • 通讯作者: *安卓玲,女,博士,主任药师,副教授·硕导,药事管理及药物代谢组学。E-mail: anzhuoling@163.com
  • 作者简介:赵瑞,女,博士,主管药师,心血管临床药学。

Pharmaceutical care of one case of luminous phenomena induced by high-dose amiodarone

ZHAO Rui, YU Xiaojia, AN Zhuoling*   

  1. Department of Pharmacy, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
  • Received:2022-07-26 Online:2023-10-15 Published:2023-10-16

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摘要： 目的 分析联合用药患者发生闪光现象（光幻视）的原因并提出处置方案,提高医师和药师对闪光现象以及药物相互作用的认识。方法 分析1例心肌梗死患者急性期出现窦性心动过速以及室性心律失常,联用多种抗心律失常药物治疗过程中,短期内出现了闪光现象,药师协助医生分析不良反应发生原因及处置的过程。结果 临床药师阐明伊伐布雷定引起闪光现象的机制,并分析药物相互作用诱导闪光现象发生,通过调整药物剂量同时安抚患者解决临床问题。结论 药师深入临床实践便于发现不良反应、防止不合理用药,提高药物的合理使用水平。

关键词: 胺碘酮, 伊伐布雷定, 药品不良反应, 药物相互作用, 闪光现象

Abstract: Objective To analyze the causes of luminous phenomena in a patient under combined medication, recommend therapies, and make physicians and pharmacists better aware of the luminous phenomena and drug interactions. Methods One patient with acute myocardial infarction developed sinus tachycardia and ventricular arrhythmia. During the treatment with a variety of antiarrhythmic drugs, luminous phenomena occurred for a short time. The pharmacist assisted the clinician in analyzing the causes of adverse reactions and recommended treatments. Results The clinical pharmacist clarified the mechanism by which luminous phenomena was caused by irvabradine. The occurrence of luminous phenomena was attributed to drug interactions. The drug dose was adjusted and the patient was soothed at the same time. Conclusion Active participation of clinical pharmacists in pharmaceutical care will help to detect adverse drug reactions as soon as possible so as to prevent irrational use of drugs.

Key words: amiodarone, irvabradine, adverse drug reaction, drug interactions, luminous phenomena

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