钠-葡萄糖协同转运蛋白-2抑制剂致不良反应分析

doi:10.19803/j.1672-8629.2021.05.16

摘要/Abstract

摘要： 目的探讨钠-葡萄糖协同转运蛋白-2（SGLT-2）抑制剂在临床使用中药品不良反应发生的规律及特点,以提高临床用药安全。方法检索中国知网、万方数据、维普网、PubMed、Embase、Medline数据库,对建库以来至2019年11月28日国内外公开发表的有关SGLT-2抑制剂致药品不良反应病例文献报道进行回顾性分析。结果共收集40例SGLT-2抑制剂致药品不良反应,共13种,前3位分别为糖尿病酮症酸中毒（55.0%）、急性胰腺炎（10.0%）、范科尼综合征（7.5%）。结论 SGLT-2抑制剂致药品不良反应表现多样,警惕其新的药品不良反应如范科尼综合征、Sweet综合征等,临床使用中应严格把控用药指征并加强用药监护。

关键词: 钠-葡萄糖协同转运蛋白-2抑制剂, 药品不良反应, 分析

Abstract: Objective To explore the characteristics and regularity of adverse drug reactions(ADR) induced by SGLT-2 inhibitors, so as to improve the safety of clinical medication. Methods CNKI, WanFang, VIP, PubMed, Embase and Medline database were retrieved from database building to November 28, 2019 and ADR induced by SGLT-2 inhibitors were analyzed retrospectively. Results A total of 40 cases of ADR induced by SGLT-2 inhibitors was enrolled in this study. Among them, 13 ADR were involved, and the top 3 types of ADR induced by SGLT-2 inhibitors were diabetic ketoacidosis (55.0%), acute pancreatitis (10.0%), fanconi syndrome (7.5%). Conclusion ADR induced by SGLT-2 inhibitors were varied, in which more attentions should be paid to new ADR such as fanconi syndrome, sweet syndrome and so on. During application of SGLT-2 inhibitors, the indications should be strict and close monitoring was necessary.

Key words: SGLT-2 inhibitors, adverse drug reactions, analysis

中图分类号:

R994.11

张厚静, 纪立伟. 钠-葡萄糖协同转运蛋白-2抑制剂致不良反应分析[J]. 中国药物警戒, 2021, 18(5): 478-482.

ZHANG Houjing, JI Liwei. Analysis of Adverse Drug Reactions Induced by SGLT-2 Inhibitors[J]. Chinese Journal of Pharmacovigilance, 2021, 18(5): 478-482.

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