中国药物警戒 ›› 2014, Vol. 11 ›› Issue (10): 601-605.

• 质量与工艺研究 • 上一篇    下一篇

银归抗纤片中白芍和黄芩的提取工艺研究

李菁1, 2, 赵玉军1, 邹建芳1 *   

  1. 1山东省职业卫生与职业病防治研究院,山东 济南 250062;
    2济南大学山东省医学科学院医学与生命科学学院,山东 济南 250022
  • 收稿日期:2014-06-18 修回日期:2016-02-03 出版日期:2014-10-08 发布日期:2016-03-02
  • 通讯作者: 邹建芳,女,主任医师,职业中毒基础与临床研究。
  • 作者简介:李菁,女,在读硕士,副主任中药师,职业病临床研究。

Study on Extraction Process of White Peony Root and Scutellaria Radix from Yingui Kangxian Tablets

LI Jing1, 2, ZHAO Yu-jun1, ZOU Jian-fang1, *   

  1. 1Shandong Academy of Occupational Health and Occupational Medicine, Shandong Jinan 250062,China;
    2School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Shandong Jinan 250022, China
  • Received:2014-06-18 Revised:2016-02-03 Online:2014-10-08 Published:2016-03-02

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摘要： 目的优选银归抗纤片中白芍和黄芩的提取工艺。方法采用L9（34）正交试验法,以乙醇浓度、乙醇用量、提取次数、提取时间为考察因素,以芍药苷含量为评价指标,优选白芍等7味药材的醇提取工艺条件;同样采用正交试验法,以加水量、提取次数、提取时间为考察因素,以黄芩苷含量为评价指标,优选黄芩等6味药材的水提取工艺条件。结果白芍的最佳醇提工艺条件为加10倍量75%乙醇回流提取3次,每次时间均为1.5 h;黄芩的最佳水提工艺条件为加8倍量水回流提取3次,每次时间均为2 h。结论优选出的白芍和黄芩提取工艺稳定、可行,可为银归抗纤片的合理开发提供部分参考依据。

关键词: 银归抗纤片, 正交试验, 提取工艺

Abstract: Objective To optimize the extraction process of white peony root and scutellaria radix in Yingui kangxian tablets. Methods Taking the concentration and consumption of ethanol, extraction times, extraction time as factors, the paeoniflorin content as index, the L9(34) orthogonal test was adopted to optimize alcohol extraction of seven Chinese herbs including white peony root. Taking the amount of water,extraction times,extraction time as factors,with the baicalin content as evaluation, orthogonal test was similarly adopted to optimize water extraction process of six Chinese herbs. Results The best alcohol extraction conditions with white peony root were as follows: extracted three times with ten times the amount of 75% ethanol, 1.5 hours per time. Optimum water extraction conditions with scutellaria radix were as follows: extracted three times with eight times the volume of water, 2 hours per time. Conclusion Optimized extraction process was stable and feasible, which could provide a reference for rational development of Yingui kangxian tablets.

Key words: Yingui kangxian tablets, orthogona1 test, extraction technology

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