中国药物警戒 ›› 2015, Vol. 12 ›› Issue (11): 656-659.

• 质量与工艺研究 • 上一篇    下一篇

不同产地牡丹皮质量及丹皮酚提取工艺研究

屈云萍1, 王娇1, 高会芹1, 李菲1, 李龙龙1, 李哲1, 姜国志2, 李振江2   

  1. 1神威药业集团有限公司,河北 石家庄 051430；
    2中药注射剂新药技术开发国家地方联合工程实验室,河北 石家庄 051430
  • 收稿日期:2015-08-19 修回日期:2016-02-02 出版日期:2015-11-08 发布日期:2016-02-02
  • 作者简介:屈云萍,女,本科,工程师,口服制剂品种工艺与质量标准研究。
  • 基金资助:
    国家中医药管理局中医药科学技术研究专项课题（国中医药科2013ZX07）; 河北省科技计划项目（14272504D）

Study on Quality of Moutan Cortex from Different Areas and Extraction Process of Paeonol

QU Yun-ping1, WANG Jiao1, GAO Hui-qin1, LI Fei1, LI Long-long1, LI Zhe1, JIANG Guo-zhi2, LI Zhen-jiang2   

  1. 1Shineway Pharmaceutical Group Ltd., Hebei Shijiazhuang 051430,China;
    2Nation and Local Engineering Laboratory for the New TCM Injection Technology Development, Hebei Shijiazhuang 051430, China
  • Received:2015-08-19 Revised:2016-02-02 Online:2015-11-08 Published:2016-02-02

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摘要： 目的分析不同产地牡丹皮的质量,研究丹皮酚提取工艺。方法对7个不同产地的牡丹皮进行含量测定,并运用SPSS软件分析提取工艺中不同因素对收率及转移率的影响。结果不同产地牡丹皮中丹皮酚含量有显著差异,连续提取及蒸馏液温度对丹皮酚收率及转移率影响较大。结论7种不同产地的牡丹皮饮片,安徽铜陵的含量最高,但陕西商洛的丹皮酚提取转移率最高。

关键词: 牡丹皮, 丹皮酚, 不同产地, 提取工艺

Abstract: ObjectiveTo analyze the quality of Moutan Cortex from different areas, and to study the extraction process of paeonol. MethodsMoutan cortex from seven different areas were assayed and the different effective factors on yield rate and percent conversion were analyzed by SPSS software. ResultsThe contents of paeonol in Moutan Cortex from different areas are significantly different. The continuous extraction and distillation temperature have a great influence for paeonol yield rate and percent conversion. ConclusionAmong the Moutan Cortex from seven different areas, the highest content occurs in the one from Tongling, Anhui province, but the highest percent conversion of paeonol occurs in the one from Shangluo, Shaanxi province.

Key words: Moutan Cortex, paeonol, different areas, extraction process

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