加减逍遥散治疗肝郁脾虚证慢性乙型肝炎疗效观察

中国药物警戒 ›› 2011, Vol. 8 ›› Issue (5): 269-271.

加减逍遥散治疗肝郁脾虚证慢性乙型肝炎疗效观察

孙建光

山东中医药大学附属医院,山东济南250011

收稿日期:2015-08-27 修回日期:2015-08-27 出版日期:2011-05-10 发布日期:2015-08-27
作者简介:孙建光,男,博士,副教授,硕士生导师,中医结合肝胆病临床研究。
基金资助:
国家重大新药创制技术专项-中药药理学研究与药效评价关键技术（2009ZX09502-015）;山东省中医药科技发展计划重点项目-慢性乙型肝炎规范化治疗方案的研究（2007Z001）

Effective Observation on Chronic Hepatitis B with Syndrome of Liver Stagnation and Spleen Deficiency Treated by Modified Xiaoyaosan

SUN Jian-guang

The Affiliated Hospital of Shangdong University of TCM, Shangdong Jinan 250011, China

Received:2015-08-27 Revised:2015-08-27 Online:2011-05-10 Published:2015-08-27

摘要/Abstract

摘要： 目的观察加减逍遥散治疗肝郁脾虚证慢性乙型肝炎临床疗效。方法临床以60例肝郁脾虚证慢性乙型肝炎患者为研究对象,随机分为试验组和对照组各30例。观察患者治疗12周后的临床证候、生化指标、免疫学指标、病原学指标等的改善情况。结果治疗12周时试验组总有效率83.33%,对照组为66.67%,试验组明显优于对照组（P<0.05）。试验组在改善中医证候、生化指标、免疫指标、HBV-DNA转阴率等方面明显优于对照组,二者有统计学差异（P<0.05）。结论逍遥散加减方可有效改善中医证候、调节细胞免疫、恢复肝功能、提高抗病毒的应答率。

关键词: 加减逍遥散, 肝郁脾虚证, 慢性乙型肝炎

Abstract: Objective To observe the clinical effection of modified Xiaoyaosan in treating chronic hepatitis B with Syndrome of liver stagnation and spleen deficiency. Methods 60 patients of chronic hepatitis B with syndrome of liver stagnation and spleen deficiency were chosen for clinical observation, and randomly divided into experimental group and control group. After12 weeks' treatment, to observe the patients' improvements such as clinical symptoms, biochemical indicators, immunological targets, pathogen indicators and so on. Results After the treatment of 12 weeks, the total efficiency of experimental group is 83.33%, and 66.67% of the control group. Experimental group was significantly better than the control group(P <0.05). The experimental group is superior to the control group in the improvement in Syndrome of TCM, biochemical, immunological indicators and HBV-DNA negative conversion rate, and there are statistical differences between the two groups(P <0.05). Conclusion Modified xiaoyaosan can effectively improve Syndrome of TCM, regulate cell immunity, restore liver function and enhance anti-viral response rate.

Key words: Modified xiaoyaosan, Syndrome of liver stagnation and spleen deficiency, Chronic Hepatitis B

中图分类号:

R282

孙建光. 加减逍遥散治疗肝郁脾虚证慢性乙型肝炎疗效观察[J]. 中国药物警戒, 2011, 8(5): 269-271.

SUN Jian-guang. Effective Observation on Chronic Hepatitis B with Syndrome of Liver Stagnation and Spleen Deficiency Treated by Modified Xiaoyaosan[J]. Chinese Journal of Pharmacovigilance, 2011, 8(5): 269-271.

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