中国药物警戒 ›› 2011, Vol. 8 ›› Issue (3): 151-153.

• 中药提纯技术研究 • 上一篇    下一篇

微波提取荆芥中胡薄荷酮的工艺研究

孙建中, 张轻轻, 王志祥   

  1. 中国药科大学制药工程教研室,江苏 南京 210009
  • 收稿日期:2015-08-27 修回日期:2015-08-27 出版日期:2011-03-10 发布日期:2015-08-27
  • 通讯作者: 王志祥,男,教授,博士生导师,制药工程领域的教学和研究。E-mail:chinawzx@sohu.com
  • 作者简介:孙建中,男,在读硕士研究生,生物化工。

Research on Microwave-assisted Extraction Process of Pulegone from Schizoepeta tenuifolia Briq

SUN Jian-zhong, ZHANG Qing-qing, WANG Zhi-xiang   

  1. Department of Pharmaceutical engineering, China Pharmaceutical University, Jiangsu Nanjing 210009, China
  • Received:2015-08-27 Revised:2015-08-27 Online:2011-03-10 Published:2015-08-27

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摘要： 目的 研究微波提取荆芥中胡薄荷酮的工艺。方法 进行单因素微波提取实验,对实验结果进行分析,着重微波功率、粉末粒径、溶剂浓度、液固比、微波温度及微波时间对胡薄荷酮提取率的影响。实验中利用气相色谱（GC）对胡薄荷酮提取率进行分析测量。结果 优化工艺为微波功率300 W,粒径40~60目,乙醇浓度60%,液固比20 mL·g-1,微波温度50℃,微波时间20 min。在此条件下,微波提取3次,胡薄荷酮的平均提取率为0.0178 35%。结论 所得实验结果稳定可靠,有助于该产品的工艺优化研究。

关键词: 胡薄荷酮, 荆芥, 微波提取, 气相色谱, 优化工艺

Abstract: Objective To investigate the technology of extracting pulegone from Schizoepeta tenuifolia Briq by microwave-assisted extraction(MAE). Methods The optimum extraction process was selected by single-factor experiments. The influences of microwave-power, particle size, the concentration of ethanol, the volume of solvent, extraction temperature and extraction time on the yield of pulegone were discussed. The yield of pulegone was analyzed and determined by GC in all the experiments. Results The Results showed that the optimum extraction conditions were established as follows: microwave-power 300 W, particle size 40-60 mesh, the concentration of ethanol 60%, the volume of solvent 20 mL·g-1, extraction temperature 50 ℃, radiation time 20 min. Extracted for 3 times, and the average yield was 0.0178 35%. Conclusion The technology process is stable and feasible. And it’s suitable for industrial production of extracting paeoniflorin by MAE.

Key words: pulegone, Schizoepeta tenuifolia Briq, MAE, GC, optimum condition

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