中国药物警戒 ›› 2015, Vol. 12 ›› Issue (6): 357-359.

• 药械安全性研究 • 上一篇    下一篇

23例芪苈强心胶囊相关洋地黄过量病例分析

李琳1,李琦1*,王金会1,赵培勇1   

  1. 1威海市立医院，山东 威海 264200;
    2烟台市市直机关医院，山东 烟台 264000
  • 收稿日期:2014-12-18 出版日期:2015-06-08 发布日期:2015-07-27
  • 通讯作者: 李琦，女，硕士，医师，内分泌学。
  • 作者简介:李琳，女，硕士，医师，心血管疾病。

Analysis of 23 cases of Qiliqiangxin Capsules in Relation to Digitalis Overdose

LI Lin1, LI Qi2*,WANG Jin-hui1,ZHAO Pei-yong1   

  1. 1Cardiovascular Department, Weihai Municipal Hospital, Shandong Weihai 264200, China;
    2Department of Endocrinology, Municipal hospital of Yantai City Government, Shandong Yantai 264000, China
  • Received:2014-12-18 Online:2015-06-08 Published:2015-07-27

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摘要： 目的 为临床安全合理使用芪苈强心胶囊提供参考依据。方法 采用化学发光免疫检验技术测定地高辛血药浓度，对监测的结果 进行统计分析。结果 在监测的258例患者中，地高辛浓度<2 ng?mL-1的有235例（91.09%），地高辛浓度≥2 ng?mL-1的有23例（8.91%），其中洋地黄中毒者7例（2.71%）。年龄对地高辛浓度有显著性差异（P＜0.05），性别对地高辛血药浓度无显著性差异（P＞0.05）。结论 监测地高辛浓度，制定个体化给药方案，对指导临床合理使用芪苈强心胶囊具有十分重要的意义。

关键词: 芪苈强心胶囊, 洋地黄过量, 地高辛浓度

Abstract: Objective To provide reference for safe, effective and reasonable use of Qiliqiangxin Capsules in clinic. Methods Serum digoxin concentration was determined by chemiluminescence immune inspection technology, and the monitoring Results were subjected to statistical analysis. Results Of the total 258 cases who were treated with Qiliqiangxin Capsules, 91.09% serum digoxin concentrations were below 2 ng?mL-1, 8.91% were above 2 ng?mL-1, with 7 cases(2.71%) having symptoms of poisoning. The concentration in the group above the age of 60 years old was higher than that in the group under 60 years old (P＜0.05). Sex had no perfect statistical mean(P＞0.05). Conclusion To ensure clinical efficacy and reduce incidence of Qiliqiangxin Capsules, it's important to monitor the serum digoxin concentration.

Key words: Qiliqiangxin capsules, digitalis overdose, serum digoxin concentration

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