中国药物警戒 ›› 2012, Vol. 9 ›› Issue (1): 7-8.

• 基础及临床研究 • 上一篇    下一篇

丙戊酸钠与双丙戊酸钠的毒性比较

黄凤娇1，李继洪1，唐敦立2，郏自明1   

  1. 1 湖北省医药工业研究院有限公司，湖北 武汉 430061；
    2 湖南省湘中制药有限公司，湖南 邵阳 422000
  • 收稿日期:2011-08-29 出版日期:2012-01-10 发布日期:2015-08-10
  • 作者简介:黄凤娇，女，助理研究员，药理毒理

Comparing the Toxicity of Valproate Sodium with Divalproex Sodium

HUANG Feng-jiao1, LI Ji-hong1, TANG Dun-li2, JIA Zi-ming1   

  1. 1 Hubei Provincial Institute of Pharmaceutical Industry CO., LTD., Hubei Wuhan 430061, China;
    2 Hunan Province Xiangzhong Pharmaceutical CO.,LTD., Hunan Shaoyang 422000, China
  • Received:2011-08-29 Online:2012-01-10 Published:2015-08-10

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摘要： 目的比较丙戊酸钠与双丙戊酸钠2种供试品毒性的大小。方法采用大鼠和小鼠2种动物，分别灌胃给予不同剂量的丙戊酸钠和双丙戊酸钠，观察大鼠和小鼠的毒性反应症状、死亡情况、病理变化，并计算出供试品对2种动物的LD50值。结果2种供试品对大鼠和小鼠的毒性反应症状及病理变化基本一致，但是在剂量相当的情况下丙戊酸钠的毒性反应症状比双丙戊酸钠的严重，死亡的动物数更多，LD50值更小。结论丙戊酸钠的毒性比双丙戊酸钠的毒性大。

关键词: 丙戊酸钠, 双丙戊酸钠, 毒性比较, LD50

Abstract: Objective To compare the toxicity of Valproate sodium with Divalproex sodium． MethodsRespectively administered different dose of Valproate sodium and Divalproex sodium to rats and mice, observed the toxicity symptoms, death and pathological change, and calculated the LD50 of the two kinds of animals. ResultsThe toxicity symptoms and pathological change are similar, but the toxicity symptoms of Valproate sodium is more serious and there are more animal death comparing with Divalproex sodium under the proximate dosage. ConclusionThe toxicity of Valproate sodium is bigger than Divalproex sodium.

Key words: Valproate sodium, Divalproex sodium, toxicity compare, LD50