丙戊酸钠缓释片致喹硫平血药浓度升高1例分析

doi:10.19803/j.1672-8629.2021.10.20

中国药物警戒 ›› 2021, Vol. 18 ›› Issue (10): 986-988.
DOI: 10.19803/j.1672-8629.2021.10.20

丙戊酸钠缓释片致喹硫平血药浓度升高1例分析

庄红艳^1,2, 刘杰^1,2, 杜海霞^1,2, 鲍爽^1,2, 赵燕^1,2, 何悦^1,2, 果伟^1,2,*

¹首都医科大学附属北京安定医院,国家精神心理疾病临床医学研究中心,精神疾病诊断与治疗北京市重点实验室,北京 100088;
²首都医科大学人脑保护高精尖创新中心,北京 100069

收稿日期:2020-02-11 出版日期:2021-10-15 发布日期:2021-10-27
通讯作者: ^*果伟,男,硕士,副主任药师,精神专科医院药学管理。E-mail：gggw@163.com
作者简介:庄红艳,女,硕士,副主任药师,精神科临床药学。
基金资助:
国家自然基金资助项目（81873398）; 首都卫生发展科研专项资助（首发2020-1-2031）; 北京市属医院科研培育计划（PX2019069）; 北京市属医院科研培育计划（PZ2020031）

Raise of Serum Concentration of Quetiapine Induced by Sodium Valproate Sustained Release Tablets and Literature Analysis

ZHUANG Hongyan^1,2, LIU Jie^1,2, DU Haixia^1,2, BAO Shuang^1,2, ZHAO Yan^1,2, HE Yue^1,2, GUO Wei^1,2*

¹Beijing Anding Hospital, Capital Medical University, The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing100088, China;
²Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100088, China

Received:2020-02-11 Online:2021-10-15 Published:2021-10-27

摘要/Abstract

摘要： 目的报道心境稳定药丙戊酸钠缓释片引起喹硫平血药浓度重度升高1例。方法对我院丙戊酸钠缓释片引起喹硫平血药浓度升高的病例进行分析,提出临床上合理使用建议。结果与结论 应加强对喹硫平和丙戊酸钠缓释片联合用药患者的药学监护,临床中应密切观察患者疗效与不良反应,定期监测患者用药的血药浓度,保证患者用药安全。

关键词: 丙戊酸钠缓释片, 喹硫平, 相互作用, 血药浓度

Abstract: Objective To report a severe increase in quintiapine serum concentration caused by taking emotional stabilizer sodium valproate sustained release tablets at the same time. Methods This paper analyzed one case of quintiapine concentration increase caused by sodium valproate sustained release tablets in our hospital, suggestions were put forward on rational use of drugs in clinic. Results and Conclusion The pharmaceutical care of patients taking quintiapine and sodium valproate sustained release tablets in combination should be strengthened. The effect and adverse reactions should be closely observed in clinical practice, and the blood concentration of both drugs should be monitored regularly to protect the drug safety of patients.

Key words: sodium valproate sustained release tablets, quintiapine, interaction, serum concentration

中图分类号:

R994.1

庄红艳, 刘杰, 杜海霞, 鲍爽, 赵燕, 何悦, 果伟. 丙戊酸钠缓释片致喹硫平血药浓度升高1例分析[J]. 中国药物警戒, 2021, 18(10): 986-988.

ZHUANG Hongyan, LIU Jie, DU Haixia, BAO Shuang, ZHAO Yan, HE Yue, GUO Wei. Raise of Serum Concentration of Quetiapine Induced by Sodium Valproate Sustained Release Tablets and Literature Analysis[J]. Chinese Journal of Pharmacovigilance, 2021, 18(10): 986-988.

参考文献

[1] Wei TX, Wei JH.Medical Manual for Physicians(医生专用药物手册)[M]. Zhengzhou:Henan Science and Technology Press, 2015: 758-760.
[2] Lu L. Shen YC.Psychiatry(精神病学)[M]. Beijing: People's Medical Publishing House, 2018: 871-875.
[3] Jin J, Wu FH.Clinical pharmacotherapy(临床药物治疗学)[M]. Shanghai: Shanghai Jiaotong University Press, 2015: 59-61.
[4] Zhao TH, Du H.Clinical observation of quetiapine combined with magnesium valproate sustained release tablets in the treatment of depressive episode of bipolar disorder[J]. Chinese Journal of Practical Rural Doctors(中国实用乡村医生杂志), 2016, 23(3): 66-67.
[5] Bai YZ.Effect observation of quetiapine combined with magnesium valproate in the treatment of bipolar disorder[J]. Clinical Medicine(临床医学), 2018, 12(6): 141-142.
[6] Chen SZ.Effect analysis of sodium valproate combined with quetiapine in the treatment of bipolar disorder manic episode[J].China Practical Medical(中国实用医药), 2019, 14(2): 83-84.
[7] Xu LL, Li CY, Lai KX, et al.Clinical study of quetiapine combined with valproate in the treatment of bipolar I disorder[J]. Journal of Clinical Psychosomatic Diseases(临床心身疾病杂志), 2018, 24(6): 37-40.
[8] Guan ZH, Dong RR, Bu Y.Effects of quetiapine combined with sodium valproate on depressive and manic symptoms in patients with bipolar disorder[J]. Strait Pharmaceutical Journal(海峡药学), 2019, 31(2):164-165.
[9] Vella T, Mifsud J.Interactions between valproic acid and quetiapine/olanzapine in the treatment of bipolar disorder and the role of therapeutic drug monitoring[J]. J Pharm Pharmacol, 2014, 66(6): 747-759.
[10] Aichhorn W, Marksteiner J, Walch T, et al.Influence of age, gender, body weight and valproate comedication on quetiapine plasma concentrations[J]. Int Clin Psychopharmacol, 2006, 21(2): 81-85.
[11] Liu Y, Meng LN. Improper secretion of antidiuretic hormone induced by quetiapine fumarate tablet: a case report[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2017, 14(2):126,128.
[12] Wang CZ.Efficacy and safety analysis of quetiapine in the treatment of acute excitability in patients with schizophrenia[J]. Clinical Research and Practice(临床医学研究与实践),2016, 1(13): 41-42.
[13] DeVane CL, Nemeroff BC. Clinical pharmacokinetics of quetiapine: an atypical antipsychotic[J]. Clin Pharmacokinet, 2001, 40: 509-522.
[14] Bakken GV, Molden E, Knutsen K, et al.Metabolism of the active metabolite of quetiapine, N-desalkylquetiapine in vitro[J]. Drug Metab Dispos, 2012, 40(9): 1778-1784.
[15] Wen X, Wang JS, Kivistö KT, et al.In vitro evaluation of valproic acid as an inhibitor of human cytochrome P450 isoforms: preferential inhibition of cytochrome P450 2C9 (CYP2C9)[J]. Br J Clin Pharmacol, 2001, 52(5): 547-553.
[16] Van der Weide K, Van der Weide J. The influence of the CYP3A4*22 polymorphism on serum concentration of quetiapine in psychiatric patients[J]. J Clin Psychopharmacol, 2014, 34(2): 256-260.
[17] Bai LD, Li WS, Cui KY, et al.Advances in genomics of quetiapine[J]. Medical frontier(医学前沿), 2016, 29(3): 206-209.
[18] Liu HM, Lin ZG, Ren JJ, et al.Preliminary exploration on reference range of serum quetiapine fumarate concentration[J]. World Clinical Drugs(世界临床药物),2012, 33(10): 612-615.
[19] Wang SY, Zeng XY, Xie HS, et al.Study on the influencing factors of serum concentration of quetiapine[J]. Shenzhen Journal of Integrated Traditional Chinese and Western Medicine(深圳中西医结合杂志), 2019, 29(10): 13-15.
[20] Tan XY, Li J.A case report on the rhabdomyolysis caused by the interaction of simvastatin[J]. Shanghai Medical & Pharmaceutical Journal(上海医药),2015, 36(13): 68-70.

丙戊酸钠缓释片致喹硫平血药浓度升高1例分析

Raise of Serum Concentration of Quetiapine Induced by Sodium Valproate Sustained Release Tablets and Literature Analysis

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	袁琪, 王颖娴, 陈思颖, 尤海生. 1例盐酸厄洛替尼片致严重皮肤溃疡和角膜穿孔的药学监护[J]. 中国药物警戒, 2023, 20(2): 206-208.
[2]	张雯雯, 聂西庭, 徐会茹, 冉晔, 田成林, 于生元. 华法林片联合复方氨酚烷胺片致凝血功能极度异常1例分析[J]. 中国药物警戒, 2023, 20(11): 1290-1292.
[3]	谢婧, 关飞. 药物诱发髂腰臀肌自发性出血1例分析[J]. 中国药物警戒, 2023, 20(11): 1299-1302.
[4]	赵瑞, 于晓佳, 安卓玲. 1例大剂量胺碘酮诱发伊伐布雷定闪光现象的药学监护[J]. 中国药物警戒, 2023, 20(10): 1173-1175.
[5]	寻晓庆, 彭玲玲. 258例癫痫患儿丙戊酸钠的血药浓度监测及影响因素分析[J]. 中国药物警戒, 2022, 19(9): 1027-1029.
[6]	张强, 杜鹏程, 满春蕊, 孙倩. 银杏叶治疗心绞痛的网络药理学研究[J]. 中国药物警戒, 2022, 19(2): 158-163.
[7]	曹鑫, 崔向丽. 移植患者伏立康唑对免疫抑制剂的浓度及临床结局影响[J]. 中国药物警戒, 2022, 19(2): 193-195.
[8]	孙倩, 陈红, 郭欣欣, 刘胜伟, 廖原, 贾玲玲. 木犀草素抗脑缺血的网络药理学研究[J]. 中国药物警戒, 2021, 18(8): 760-762.
[9]	程夏龙, 张许来, 吴晓平, 戴彪, 王安珍, 严凡凡. 阿立哌唑对老年痴呆伴精神障碍患者代谢影响及疗效与血药浓度相关性研究[J]. 中国药物警戒, 2021, 18(7): 641-644.
[10]	朱丽丽, 耿伟, 袁圆, 安晓婕, 袁双丽, 郦昱琨, 陈渤松, 赵军. 他克莫司在儿童肾病中的风险预测模型的建立[J]. 中国药物警戒, 2021, 18(6): 579-583.
[11]	张泰, 王岩艳. 药用辅料影响诊疗安全研究进展[J]. 中国药物警戒, 2021, 18(5): 492-494.
[12]	吕锦涛, 张丹, 张冰, 萨日娜, 林志健, 张晓朦. 柑橘属中药的药物相互作用研究进展[J]. 中国药物警戒, 2021, 18(5): 495-498.
[13]	杨晓雯, 王晓星. 环孢素联合用药致高钾血症1例及文献分析[J]. 中国药物警戒, 2021, 18(12): 1192-1195.
[14]	杨鸣, 罗辉, 刘建平. 中药-化药相互作用临床研究方法的国内外研究进展[J]. 中国药物警戒, 2021, 18(11): 1029-1033.
[15]	程金莲, 欧阳绘天, 靳洪涛, 朱雪琦, 肖爽, 雷翔, 高春升, 刘清泉. 中药临床研究联合用药安全性评价的思考和建议[J]. 中国药物警戒, 2021, 18(1): 4-10.