关键词: 柳氮磺吡啶肠溶片, 药物超敏反应综合征, 肝功能损害, 皮疹, 淋巴结肿大, 药品不良反应

Abstract: Objective To analyze one case of drug-induced hypersensitivity syndrome caused by sulfasalazine in order to provide a reference for clinical use. Methods One case of drug hypersensitivity syndrome caused by sulfasalazine enteric-coated tablets in a patient with colitis was analyzed to explore the possible mechanisms, clinical manifestations and preventive measures related to drug hypersensitivity syndrome. Results After being treated with sulfasalazine enteric-coated tablets for 1 month, the patient presented with liver function damage, scattered rashes all over the body, multiple lymphadenopathy, and significantly elevated atypical lymphocytes in peripheral blood, which was considered to be drug-induced hypersensitivity syndrome caused by sulfasalazine enteric-coated tablets and the conclusion was “probable”. The patient was in better condition after treatment with glucocorticoids, TNF-α inhibitors, liver protection, and anti-allergy. Conclusion Drug hypersensitivity syndrome is a rare adverse reaction of sulfasalazine with a long incubation period and various clinical manifestations. In case of abnormal liver function, rash, lymphadenopathy and abnormal results of hematological examination, clinicians should be highly vigilant against drug hypersensitivity syndrome when sulfasalazine is used.

Key words: Sulfasalazine Enteric-Coated Tablets, Drug-Induced Hypersensitivity Syndrome, Liver Function Damage, Skin Rash, Lymphadenopathy, Adverse Drug Reactions