抗菌药物致中毒性表皮坏死松解症1例

doi:10.19803/j.1672-8629.2020.08.18

中国药物警戒 ›› 2020, Vol. 17 ›› Issue (8): 535-538.
DOI: 10.19803/j.1672-8629.2020.08.18

抗菌药物致中毒性表皮坏死松解症1例

罗晓枫¹, 杜倩², 奚鑫², 冉海龙^2,*

¹重庆医科大学药学院,重庆 400016;
²重庆医科大学附属第三医院（捷尔医院）药剂科,重庆 401120

收稿日期:2020-07-31 修回日期:2020-07-31 出版日期:2020-08-15 发布日期:2020-07-31
通讯作者: ^*冉海龙,女,硕士,药师,临床药学。E-mail：ranhailong@hospital.cqmu.edu.cn
作者简介:罗晓枫,女,本科,临床药学。

One Case of Toxic Epidermal Necrolysis Induced by Antibacterial Drugs

LUO Xiaofeng¹, DU Qian², XI Xin², RAN Hailong^2,*

¹School of Pharmacy, Chongqing Medical University, Chongqing 400016, China;
²Department of Pharmacy, the Third Affiliated Hospital of Chongqing Medical University(Gener Hospital), Chongqing 401120, China

Received:2020-07-31 Revised:2020-07-31 Online:2020-08-15 Published:2020-07-31

摘要/Abstract

摘要： 目的提醒临床医生在使用抗菌药物时应密切关注用药安全。方法分析1例45岁男性患者先后静脉滴注哌拉西林他唑巴坦、亚胺培南西司他丁、左氧氟沙星后出现中毒性表皮坏死松解症（TEN）的病例资料,文献回顾TEN的发病机制和治疗措施。结果该患者由哌拉西林他唑巴坦、亚胺培南西司他丁、左氧氟沙星引起TEN的可能性大,经过及时停药,积极抗过敏、系统免疫治疗及对症支持治疗后,患者皮肤症状逐渐缓解。结论哌拉西林他唑巴坦、亚胺培南西司他丁、左氧氟沙星致TEN的发生率低,但病死率高,预后差,应引起临床重视。

关键词: 哌拉西林钠他唑巴坦, 亚胺培南西司他丁, 左氧氟沙星, 中毒性表皮坏死松懈症

Abstract: Objective To remind the medical staff to pay close attention to medication safety of antibacterial drugs. Methods One case of toxic epidermal necrolysis (TEN) after intravenous infusion of piperacillin tazobactam, imipenem/cilastatin, and levofloxacin in a 45-year-old male patient was analyzed while literature about the pathogenesis and treatment of TEN was reviewed. Results Toxic epidermal necrolysis was most likely to be induced by piperacillin tazobactam, imipenem/cilastatin, and levofloxacin in this patient. The symptoms on the patient's skin were relieved gradually via timely discontinuation of the drugs, anti-allergic therapy, systemic immunotherapy, and symptomatic supportive treatment. Conclusion Toxic epidermal necrolysis induced by piperacillin tazobactam, imipenem/cilastatin, and levofloxacin is a disease with low incidence, but with a high mortality and poor prognosis, which deserves attention.

Key words: piperacillin sodium tazobactam, imipenem cilastatin sodium, levofloxacin, toxic epidermal necrosis

中图分类号:

R994.11

罗晓枫, 杜倩, 奚鑫, 冉海龙. 抗菌药物致中毒性表皮坏死松解症1例[J]. 中国药物警戒, 2020, 17(8): 535-538.

LUO Xiaofeng, DU Qian, XI Xin, RAN Hailong. One Case of Toxic Epidermal Necrolysis Induced by Antibacterial Drugs[J]. Chinese Journal of Pharmacovigilance, 2020, 17(8): 535-538.

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抗菌药物致中毒性表皮坏死松解症1例

One Case of Toxic Epidermal Necrolysis Induced by Antibacterial Drugs

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