中国药物警戒 ›› 2011, Vol. 8 ›› Issue (10): 624-626.

• 药品不良反应监测 • 上一篇    下一篇

89例严重药品不良反应/事件报告分析

范平平   

  1. 大连市药品不良反应监测中心,辽宁 大连 116021
  • 收稿日期:2010-12-03 出版日期:2011-10-10 发布日期:2015-07-30
  • 作者简介:范平平,女,药品不良反应监测。

Analysis of 89 Severe Adverse Drug Reaction/ Event Reports

FAN Ping-ping   

  1. Dalian Medicine Adverse Reaction Monitoring Center, Liaoning Dalian 116021, China
  • Received:2010-12-03 Online:2011-10-10 Published:2015-07-30

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摘要： 目的 探讨严重药品不良反应/事件(ADR/ADE)发生的特点、一般规律及处理措施,为临床安全用药提供参考。方法 对大连市药品不良反应监测中心2008年1月至2010年4月收集到的89例严重ADR/ADE进行统计分析。结果 女性患者及老年患者的严重ADR/ADE发生率较高;静脉滴注所引起的严重ADR/ADE明显高于其他给药途径;在涉及的所有药物中,抗微生物药及中药占比例较大。结论 临床对女性及老年患者用药时应格外谨慎;若无必要应尽量避免多药联用及静脉给药;对于易产生过敏反应的药物,在用药前可采取一定的预防措施。

关键词: 严重, 不良反应/事件, 报告分析

Abstract: Objective To investigate the features, general pattern and preventive measures of the severe adverse drug reaction/event(ADR/ADE), and provide references of clinical rational and safe use of drug. Methods 89 ADR/ADE cases collected in Dalian Medicine Adverse Reaction Monitoring Center from Jan. 2008 to Apr. 2010 were analyzed retrospectively. Results The females and aged patients have a higher incidence of severe ADR/ADE; most cases were induced by intravenous drip; and more cases were caused by antimicrobial agents and Chinese medicine. Conclusion Medical workers should pay more attention to females and aged patients; intravenous drip and drug combination should be avoided if it is not necessary; Preventive action could be taken before using sensitizing drugs.

Key words: severe, adverse drug reaction/event(ADR/ADE), analysis of reports

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