中国药物警戒 ›› 2018, Vol. 15 ›› Issue (1): 12-15.

• 研究基础 • 上一篇    下一篇

黄蜀葵花总黄酮联合格列吡嗪对糖尿病肾病模型大鼠的治疗作用

李萌, 宋春泉1, 王帅1, 薛云2, 马玉奎2,*   

  1. 1 青岛市中心医院药学部,山东 青岛 266042;
    2 山东省药学科学院,山东 济南 250100;
  • 收稿日期:2018-02-12 修回日期:2018-02-12 出版日期:2018-01-20 发布日期:2018-02-12
  • 通讯作者: *马玉奎,男,博士,主任药师,新药药理毒理评价。E-mail：mayk@sdapsglp.cn
  • 作者简介:李萌,男,硕士,副主任药师,临床药理学。
  • 基金资助:
    中央引导地方科技发展专项：创新药物临床前评价公共服务平台

Effects of Total Flavone of Abelmoschl Manihot Combined with Glipizide on Model Rats of Diabetic Nephropathy

LI Meng1, SONG Chun-quan1, WANG Shuai1, XUE Yun2, MA Yu-kui2,*   

  1. 1 Qingdao Central Hospital, Shandong Qingdao 266042, China;
    2 Shandong Pharmaceutical Academy, Shandong Jinan 250100, China;
  • Received:2018-02-12 Revised:2018-02-12 Online:2018-01-20 Published:2018-02-12

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摘要： 目的 研究黄蜀葵花总黄酮（TFA）联合格列吡嗪对GK糖尿病肾病（DN）模型大鼠有无辅助治疗作用。方法 采用GK大鼠饲喂高脂高蛋白饲料制备DN模型,以糖化血红蛋白、血脂和内皮素水平;血液流变学和肾功能指标;肾脏系数以及肾脏病理组织学为考察指标,全面评价应用格列吡嗪的同时给予TFA对DN模型大鼠的辅助治疗作用。结果 与格列吡嗪组比较,应用格列吡嗪同时给予TFA（50、100 mg·kg-1,ig）可明显降低DN模型大鼠血浆中血脂、内皮素、BUN、CR和尿微量白蛋白水平以及血黏度,可减小肾脏系数,减轻肾脏病理组织学病变。结论 应用降糖药同时给予TFA对DN模型大鼠的肾脏具有明显的保护作用。

关键词: 黄蜀葵花总黄酮, 糖尿病肾病, 糖化血红蛋白, GK大鼠

Abstract: ：Objective To investigate the effects of total flavone of Abelmoschl manihot(TFA) combined with glipizide on GK model rats of diabetic nephropathy. Methods The GK model rats were induced by high-calorie and high-protein diet. The level of glycosylated hemoglobin, blood fat, indothelin, urinary microalbumin, blood rheology, renal function, indexes and pathology of renal were determined to evaluate the auxiliary therapeutic effects of TFA on model rats of diabetic nephropathy． Results Compared with glipizide group, the level of glycosylated hemoglobin, blood fat, indothelin, urinary microalbumin, BUN, CR, blood viscosity and indexes of renal was decreased, at the same time pathological changes of kidney were alleviated significantly in glipizide plus TFA(50、100 mg·kg-1, i.g) groups． Conclusion TFA has a remarkable auxiliary therapeutic effect on GK model rats of diabetic nephropathy．

Key words: total flavone of Abelmoschl manihot, diabetic nephropathy, glycosylated hemoglobin, GK rat

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