中国药物警戒 ›› 2017, Vol. 14 ›› Issue (7): 399-401.

• 基础与临床研究 • 上一篇    下一篇

文拉法辛和度洛西汀治疗老年功能性消化不良的临床疗效与安全性的回顾性分析

赵飞1, 屠继军2*   

  1. 1 平顶山市第二人民医院,河南 平顶山 467000;
    2 宜兴市人民医院,江苏 宜兴 214200
  • 收稿日期:2017-08-16 修回日期:2017-08-16 出版日期:2017-07-20 发布日期:2017-08-16
  • 通讯作者: 屠继军,男,本科,副主任医师,消化内科。E-mail：luoguxt123@163.com
  • 作者简介:赵飞,男,本科,主治医师,消化内科。

Retrospective Analysis about Efficacy and Safety of Venlafaxine and Duloxetine in Treatment of Senile Functional Dyspepsia

ZHAO Fei1, TU Ji-jun2,*   

  1. 1 2ed People's Hospital of Pingdingshan, Henan Pingdingshan 467000, China;
    2 Department of Gastroenterology, Yixing People's Hospital, Jiangsu Yixing 214200, China
  • Received:2017-08-16 Revised:2017-08-16 Online:2017-07-20 Published:2017-08-16

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摘要： 目的 探讨文拉法辛和度洛西汀治疗老年功能性消化不良的临床疗效与安全性。方法 回顾分析2015年6至2016年9月就诊于某院的96例老年功能性消化不良（FD）患者,根据的用药方案分为度洛西汀组50例和文拉法辛组46例,度洛西汀组予基础治疗+盐酸度洛西汀,文拉法辛组予基础治疗+盐酸文拉法辛,连续服药12周。比较两组治疗前后的PHQ-9评分和不良反应,并采用一元线性回归分析对比两组的疗效差异。结果 治疗后度洛西汀组PHQ-9评分显著低于文拉法辛组,差异具有统计学意义（P<0.05）。治疗后度洛西汀组无抑郁患者比例显著高于文拉法辛组,差异具有统计学意义（P<0.05）;回归分析显示度洛西汀组的疗效约为文拉法辛组的2倍,且有统计学意义（P<0.05）。度洛西汀组显效率显著高于文拉法辛组（P<0.05）;两组患者治疗期间均未见严重不良反应。结论 与文拉法辛相比较,度洛西汀治疗FD的疗效相对较好,不良反应较少。

关键词: 功能性消化不良, 文拉法辛, 度洛西汀, 临床疗效

Abstract: Objective To evaluate the clinical efficacy and safety of venlafaxine and duloxetine in the treatment of senile functional dyspepsia (FD). Methods Retrospective analysis the data of 96 cases senile functional dyspepsia which had treated in a hospital, from June 2015 to September 2016. All patients divided into venlafaxine group and duloxetine group. The venlafaxine treated with basic treatment+venlafaxine, while duloxetine treated with basic treatment+duloxetine, continuously for 12 weeks. Compared the PHQ-9 scores and adverse reaction, the the difference of curative effect between two groups analyzed by linear regression analysis. Results After treatment, the PHQ-9 scores of duloxetine group was significantly lower than venlafaxine group, and the difference was statistically significant (P <0.05). The non-depression rate of duloxetine group was higher than venlafaxine group, and the difference was statistically significant (P <0.05). Regression analysis showed that the efficacy of duloxetine group was about 2 times that of venlafaxine group, and had statistically significant (P <0.05). The effective rate of duloxetine group was significantly higher than venlafaxine group (P <0.05), and there was no serious adverse reaction in the two groups during treatment. Conclusion Compared with venlafaxine, duloxetine has better efficacy and less adverse effects in the treatment of FD.

Key words: functional dyspepsia, venlafaxine, duloxetine, clinical efficacy

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