复方花生衣颗粒改善化疗后血小板减少症状的临床疗效与安全性分析

中国药物警戒 ›› 2017, Vol. 14 ›› Issue (4): 209-211.

复方花生衣颗粒改善化疗后血小板减少症状的临床疗效与安全性分析

陈祥

芜湖市中医医院肿瘤科,安徽芜湖 241000

收稿日期:2017-07-05 修回日期:2017-07-05 出版日期:2017-04-20 发布日期:2017-07-05
作者简介:陈祥,男,本科,主治医师,中西结合治疗肿瘤疾病。

Clinical Efficacy and Safety Analysis on Fufanghuashengyi Granules in Treatment of Thrombocytopenia Induced by Chemotherapy

CHEN Xiang

Department of Oncology, Wuhu Hospital of Traditional Chinese Medicine,Anhui Wuhu 241000, China

Received:2017-07-05 Revised:2017-07-05 Online:2017-04-20 Published:2017-07-05

摘要/Abstract

摘要： 目的考察复方花生衣颗粒改善化疗后血小板减少症状的临床疗效与安全性。方法选取2013年3月至2016年3月在我院诊治的肿瘤患者80例,根据患者化疗后所致的血小板减少症状的分度标准进行分组治疗,I和II度患者采用随机数字法分为对照组（40例,给予常规治疗）和治疗组（40例,给予复方花生衣颗粒治疗）,比较两组患者的临床疗效及安全性差异。结果与对照组相比,治疗组在治疗后PLT计数、Hb水平及PLT的最低值均显著升高,PLT恢复至50或100×109·L^-1时间显著缩短,差异具有统计学意义（P<0.05）;Logistic多元回归模型结果显示,复方花生衣颗粒对恶心呕吐、发热、乏力和水肿等不良反应具有显著的拮抗作用（P<0.05）。结论复方花生衣颗粒治疗I和II度化疗后血小板减少症的临床疗效均较好,且安全性较高,值得推广应用。

关键词: 复方花生衣颗粒, 化疗, 血小板减少

Abstract: Objective To investigate the clinical efficacy and safety of Fufanghuashengyi granules in treatment of thrombocytopenia induced by chemotherapy. Methods 80 cases of cancer patients were collected from March 2013 to March 2016 in our hospital, according to the grade of thrombocytopenia induced by chemotherapy, I and II degree patients were divided into control group (40 cases, given conventional therapy) and treatment group (40 cases, given Fufanghuashengyi granules) using random digital method, compared the clinical efficacy and safety differences of the two groups. Results Compared with the control group, the PLT, Hb count and the minimum value of PLT of treatment group both significantly increased, the time of PLT back to 50 or 100×109·L^-1 significantly shortened, with statistical significance (P<0.05). Logistic multiple regression model showed that Fufanghuashengyi granules had significantly antagonistic effect to vomiting, fever, fatigue and edema (P<0.05). Conclusion Fufanghuashengyi granules in treatment of I and II degree thrombocytopenia induced by chemotherapy has good clinical effect, and safety is relatively high, it is worth to be popularized and applied.

Key words: Fufanghuashengyi granule, chemotherapy, thrombocytopenia

中图分类号:

R969

陈祥. 复方花生衣颗粒改善化疗后血小板减少症状的临床疗效与安全性分析[J]. 中国药物警戒, 2017, 14(4): 209-211.

CHEN Xiang. Clinical Efficacy and Safety Analysis on Fufanghuashengyi Granules in Treatment of Thrombocytopenia Induced by Chemotherapy[J]. Chinese Journal of Pharmacovigilance, 2017, 14(4): 209-211.

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