中国药物警戒 ›› 2017, Vol. 14 ›› Issue (2): 71-74.

• 基础与临床研究 • 上一篇    下一篇

降脂利肝颗粒联合辛伐他汀治疗非酒精性脂肪肝的临床疗效观察

卞晓岚1, 2, 郑岚3*   

  1. 1 上海交通大学医学院附属瑞金医院卢湾分院药剂科,上海 200020;
    2 上海交通大学医学院附属瑞金医院药剂科,上海 200025;
    3 上海交通大学医学院附属瑞金医院中医科,上海 200025
  • 收稿日期:2017-03-10 修回日期:2017-03-10 出版日期:2017-02-20 发布日期:2017-03-10
  • 通讯作者: 郑岚,女,硕士,主任医师,中医内科学。E-mail：windy9453@126.com
  • 作者简介:卞晓岚,女,硕士,主任药师,医药药学和医院制剂。
  • 基金资助:
    上海市黄浦区卫生系统2013-2016年度优秀学科带头人项目

Clinical Efficacy of Jiangzhiligan Granules Combined with Simvastatinin in Treatment of Non-alcoholic Fatty Liver Disease

BIAN Xiao-lan1, 2, ZHENG Lan3, *   

  1. 1 Department of Pharmacy, Luwan Branch of RuiJin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai 20002;
    2 Department of Pharmacy, RuiJin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;
    3 Department of Traditional Chinese Medicine, RuiJin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai 200025
  • Received:2017-03-10 Revised:2017-03-10 Online:2017-02-20 Published:2017-03-10

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摘要： 目的 探讨降脂利肝颗粒联合辛伐他汀治疗非酒精性脂肪肝（NAFLD）的临床疗效。方法 选取2014年1月至2015年12月我院收治的86例NAFLD患者作为研究对象,通过随机数字表法分为对照组和研究组各43例。对照组给予口服辛伐他汀片治疗,研究组在对照组治疗方案的基础上加用降脂利肝颗粒治疗,疗程均为3个月。观察治疗前后两组患者的肝生化指标和血脂水平的变化,评价两组治疗的临床疗效。结果 治疗3个月后,两组患者的ALT、AST、GGT水平均较治疗前下降,研究组下降更为明显,差异有统计学意义（P<0.05）。两组患者经治疗后的TG、TC、LDL-C水平均较治疗前下降,HDL-C较治疗前升高,研究组变化更为明显,差异有统计学意义（P<0.05）。两组患者经治疗后的SOD活力明显升高, MDA水平明显下降,且研究组变化更为明显,差异有统计学意义（P<0.05）。研究组临床总有效率（90.70%）明显高于对照组（72.09%）,差异有统计学意义（P<0.05）。两组患者治疗后均未见不良反应发生,安全性较好。结论 降脂利肝颗粒联合辛伐他汀可以明显改善NAFLD患者的肝生化指标和血脂代谢,且安全性较好,具有临床推广价值。

关键词: 降脂利肝颗粒, 辛伐他汀, 非酒精性脂肪肝, 临床疗效

Abstract: Objective To investigate the clinical efficacy of Jiangzhiligan granules combined with simvastatin in the treatment of non-alcoholic fatty liver disease (NAFLD).Methods 86 patients with NAFLD from January 2014 to December 2015 in our hospital were selected and divided into control group (43 cases) and research group (43 cases) by the random number table method. Patients in the control group were given simvastatin tablets, while the research group was treated with the supplementary Jiangzhiligan granules. The treatment course of the two groups was both 3 months. The changes of liver biochemical indexes and serum lipid before and after the treatment were observed, the clinical efficacy of the two groups was evaluated.Results Compared with the levels before treatment, the ALT, AST, GGT in both of the two groups decreased significantly after 3 months treatment, and the changes of the observation group were more obvious, the difference was statistically significant (P < 0.05). The TG, TC, LDL-C in both of the two groups decreased significantly, and the HDL-C increased significantly after treatment, the changes of the research group were more obvious, the difference was statistically significant (P < 0.05). The SOD in both of the two groups increased significantly, and the MDA decreased significantly after treatment, the changes of the research group were more obvious, the difference was statistically significant (P < 0.05). The total effective rate in the observation group was 90.70%, which was significantly higher than that in the control group of 72.09%, the difference was statistically significant (P <0.05). No adverse reactions were found in the two groups after treatment, and the safety was good.Conclusion Jiangzhiligan granules combined with simvastatin can significantly improve liver biochemical indexes and serum lipid of patients with NAFLD, and has good safety and clinical value.

Key words: Jiangzhiligan granule, simvastatin, non-alcoholic fatty liver disease, clinical efficacy

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