中国药物警戒 ›› 2016, Vol. 13 ›› Issue (4): 197-200.

• 基础与临床研究 • 上一篇    下一篇

牛蒡子苷元注射液对清醒Beagle犬心血管系统和呼吸系统的影响

高雷1,姚景春1,孙颖1,李涛1,王三龙2   

  1. 1鲁南制药集团股份有限公司新药药理中心,中药制药共性技术国家重点实验室药效学研究中心,山东 临沂 273400 ;
    2中国食品药品检定研究院国家药物安全评价监测中心,北京 100176
  • 收稿日期:2015-12-14 修回日期:2016-06-30 出版日期:2016-04-20 发布日期:2016-06-30
  • 通讯作者: 王三龙,男,主任药师,药理毒理实验研究。E-mail:wangsanlong@nifdc.org.cn
  • 作者简介:高雷,男,工程师,药理毒理实验研究。
  • 基金资助:
    山东省自主创新及成果转化专项（创新型产业集群）:2015ZDJQ05004。

Effects of Arctigenin Injection on the Cardiovascular System and Respiratory System in Conscious Beagle Dog

GAO Lei1, YAO Jing-chun1, SUN Ying1, LI Tao1, WANG San-long2   

  1. 1.Center for New Drug Pharmacology of Lunan Pharmaceutical Group Co.Ltd. Center for Pharmacodynamic Research of State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Shandong Linyi 273400, China;
    2.National Center for Safety Evaluation of Drugs, National Institute for Food and Drug Control, Beijing 100176, China
  • Received:2015-12-14 Revised:2016-06-30 Online:2016-04-20 Published:2016-06-30

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摘要： 目的 通过对预先埋植有DSI遥测植入子的清醒Beagle犬皮下注射给予牛蒡子苷元注射液（NBZGY）,评价对Beagle犬心血管系统和呼吸系统产生的潜在影响。方法 采用8只已经成功埋植DSI遥测植入子（TL11M2-D70-PCTR）的Beagle犬,皮下注射给予NBZGY（0.05~5 mg·kg-1）,每只清醒Beagle犬将在4个独立的给药日分别给予溶媒及3个剂量的NBZGY,每次给药间隔（含给药日）为2天。通过生理信号遥测系统连续测量和记录给药前、给药后1、1.5、2、3、4、5、6、12、24 h的心电（RR间期、心率、T波振幅、ST段、QRS间期、PR间期、QT间期）、体温、血压（收缩压、舒张压、平均压）、呼吸（潮气量、呼吸频率）等指标。结果 给药后1、2、24 h,部分指标与同期溶媒对照组相比具有统计学意义（P<0.05）,但因差异无剂量依赖性,故无生物学意义。结论 本实验条件下,Beagle犬皮下注射给予NBZGY,心血管系统和呼吸系统均未见与供试品相关的明显改变。

关键词: 生理信号遥测系统, 牛蒡子苷元注射液, 心血管系统, 呼吸系统

Abstract: Objective To evaluate the effects of arctigenin injection（NBZGY）on the cardiovascular system and the respiratory system by subcutaneous administration in conscious Beagle dogs that implanted with telemetry transmitters. Methods Eight Beagle dogs with telemetry transmitters（TL11M2-D70-PCTR）were subcutaneously administrated with NBZGY injection (0.05~5 mg·kg-1) and 30% PEG (normal control). All dogs received normal control and NBZGY injection in sequence every other day. The ECG (RR interval, heart rate, T wave, ST segment, QRS interval, PR interval, QT interval), body temperature, blood pressure (systolic blood pressure, diastolic blood pressure, mean blood pressure) and respiratory (tidal volume, respiratory rate) data were continuously monitored for at least 2 h before dosing and 1, 1.5, 2, 3, 4, 5, 6, 12 and 24 h after dosing. Results Compared with the vehicle control group at 1, 2, 24 h after dosing, tidal volume, respiratory rate increased significantly（P<0.05）, RR interval,diastolic blood pressure, mean blood pressure reduced significantly（P<0.05）. Conclusion Under these study condictions,no obvious change in the cardiovascular system and the respiratory system of Beagle dogs was found after subcutaneous administration with NBZGY.

Key words: telemetry system, arctigenin injection, cardiovascular system, respiratory system

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