中国药物警戒 ›› 2016, Vol. 13 ›› Issue (2): 78-79.

• 质量与工艺研究 • 上一篇    下一篇

正交法筛选莪术油霜剂基质的研究

洪博， 李文静*， 蔡德富， 牛英才， 李晓明， 李成冲， 邹宇   

  1. 齐齐哈尔医学院暨药学院， 黑龙江 齐齐哈尔 161006
  • 收稿日期:2016-03-14 修回日期:2016-03-14 出版日期:2016-02-08 发布日期:2016-03-14
  • 通讯作者: 李文静,男,硕士, 讲师,中药药物分析。E-mail: lwj022325@163.com
  • 作者简介:洪博，女，博士，讲师，中药新药研究与开发。
  • 基金资助:
    黑龙江省卫生厅科研课题项目（2012-327）

Optimal Selection of Base Composition of Ointment of Curcuma Oil by Orthogonal Design

HONG Bo, LI Wen-jing*, NIU Ying-cai, LI Xiao-ming, LI Cheng-chong, ZOU Yu   

  1. Department of Pharmacy, Qiqihar Medical University, Heilongjiang Qiqihar 161006, China
  • Received:2016-03-14 Revised:2016-03-14 Online:2016-02-08 Published:2016-03-14

PDF (PC)

224

摘要： 目的确定莪术油霜剂最佳基质配比。方法采用正交实验设计法和高效液相色谱法，以外观和莪术油的含量为检测指标，确定霜剂基质的最佳配比。结果复方莪术油霜剂的最佳基质配方为:单硬脂酸甘油酯32 g，甘油70 mL，白凡士林18 g，蒸馏水500 mL。结论此配比基质得到的霜剂稳定，有效成分含量高。

关键词: 正交设计, 莪术油霜剂, 基质

Abstract: ObjectiveTo determine the best formula of ointment of curcuma oil. MethodsThe best formula was determined by orthogonal design and high performance liquid chromatography methods, using appearance of the ointment and the contents of effective components as the test index. ResultsThe optimal formula was determined as followed: glyceryl monostearate 32 g, glycerin 70 mL, albolene 18 g, distilled water 500 mL. ConclusionThe ointment with high effective components obtained from this formula is stable.

Key words: orthogonal design, ointment of curcuma oil, base composition

中图分类号: