中国药物警戒 ›› 2011, Vol. 8 ›› Issue (8): 501-503.

• 药品不良反应监测 • 上一篇    下一篇

47例鱼精蛋白致严重低血压不良反应分析

江腊梅1, 赵燕2   

  1. 1 济南市药品不良反应医疗器械不良事件监测中心,山东 济南250001;
    2 国家药品评价中心,北京 100045
  • 收稿日期:2011-05-08 出版日期:2011-08-10 发布日期:2015-07-30
  • 作者简介:江腊梅,女,主任药师,药品不良反应监测。

Analysis of 47 ADR Cases of Severe Hypotension Induced by Protamine

JIANG La-mei1, ZHAO-Yan2   

  1. 1 Jinan Adverse Drug Reaction Monitoring Center of Medical Device Adverse Events, Shandong Jinan 250001, China;
    2 Center for Drug Reevaluation, SFDA, Beijing 100045, China
  • Received:2011-05-08 Online:2011-08-10 Published:2015-07-30

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摘要： 目的 分析心脏手术中鱼精蛋白中和肝素导致严重低血压、气道压力升高及临床应急治疗。方法 回顾性分析我市2009~2010年上报鱼精蛋白不良反应47例病例。47例患者在用药后出现中度和重度血压降低30~50mmHg的38例,轻度血压降低20~29mmHg的9例。结果 经过积极抢救治疗和输血等措施,在不良反应发生5min之内血压恢复正常的40例,占85.11%;7例除药物治疗外,同时重新建立体外循环、手动控制呼吸等10~30min内好转。结论 鱼精蛋白导致严重低血压反应难以预测,手术进行中必要的预防和积救治措施是降低鱼精蛋白严重不良反应的的关键。

关键词: 鱼精蛋白, 中和肝素, 严重低血压, 治疗

Abstract: Objective To analyze the adverse reaction of severe hypotension and rise of tracheal pressure due to Protamine combined with heparin in heart surgery and clinical emergency treatment. Methods To analyze retrospectively 47 severe ADR cases of Protamine from 2009 to 2010 in Jinan. 38 patients were caused moderate or severe hypertension(blood pressure decreased by 30~≥50mmHg) after Protamine injection, 9 patients were caused slight hypertension(blood pressure decreased by 20~29mmHg). Results After emergency treatment and blood transfusion, 40 cases returned to normal blood pressure in 5min, 85.11% in 47 patients. While 7 patients had been improved in 10~30min through extracorporeal circulation rebuilt and manually controlled respiration besides of the medicine treatment. Conclusion Protamine may cause severe hypotension. In surgery, the preventive measures and active treatment is the key to lower the occurring rate of severe ADR.

Key words: Protamine, combined with heparin, severe hypotension, treatment

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