中国药物警戒 ›› 2013, Vol. 10 ›› Issue (3): 163-165.

• 药械安全性研究 • 上一篇    下一篇

40例盐酸氨溴索注射剂致严重不良反应/事件分析

黄元,李泮海,田月洁   

  1. 山东省药品不良反应监测中心,山东济南 250013
  • 收稿日期:2012-05-07 修回日期:2016-03-09 出版日期:2013-03-08 发布日期:2016-03-09
  • 作者简介:黄元,女,主管药师,药品不良反应监测。

Analysis of 40 Cases of Adverse Drug Reactions/Event Induced by Ambroxol Hydrochloride Injection

HUANG Yuan ,LI Pan-hai ,TIAN Yue-jie   

  1. Shandong Center for ADR Monitoring, Shandong Jinan 250013, China
  • Received:2012-05-07 Revised:2016-03-09 Online:2013-03-08 Published:2016-03-09

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摘要： 目的 探讨盐酸氨溴索注射剂致严重不良反应/事件（ADR/ADE）的一般规律、特点及影响因素,为临床用药提供参考。方法 对我中心2011 年收集到的40 例由盐酸氨溴索注射剂引起的严重不良反应/ 事件报告进行统计、分析。结果 患者集中分布在14 岁以下和45 岁以上,二者合计95%；严重不良反应表现主要为急性过敏样反应的症状；在30min 内发生ADR的占总例数的92.5%。结论 盐酸氨溴索注射剂致严重不良反应的发生与多种因素有关,对其引起的急性过敏样反应应高度重视,用药过程中必须严密监测。

关键词: 盐酸氨溴索注射剂, 药品不良反应/事件, 分析

Abstract: Objective To probe into the status,characterstics and influencing factors of ADR/ADE cases induced by Ambroxol Hydrochloride injection. Methods We analyzed 40 ADR/ADE cases induced by ambroxol hydrochloride injection which were collected by Shandong ADR monitoring network from Jan. to Dec. of 2011. Results 95% of the patients were under 14 or more than 45 years old. The symptoms of serious ADR were mainly anaphylactoid reactions. 92.5% of ADR/ADE appeared within 30 min. Conclusion Serious ADR/ADE can be caused by a variety of factors. High attention should be paid to acute anaphylactoid reactions. Ambroxol hydrochloride injection should be used with more caution and exact monitoring.

Key words: ambroxol hydrochloride injection, adverse drug reactions/event(ADR/ADE）, analysis

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