中国药物警戒 ›› 2013, Vol. 10 ›› Issue (11): 683-686.

• 药械安全性研究 • 上一篇    下一篇

质子泵抑制剂不良反应文献分析

王安起   

  1. 北京市顺义区中医医院,北京 101300
  • 收稿日期:2013-04-15 修回日期:2016-03-09 出版日期:2013-11-08 发布日期:2016-03-09
  • 作者简介:王安起,男,副主任药师,临床药学。

Literature Analysis of Adverse Drug Reaction Induced by Proton Pump Inhibitors

WANG An-qi   

  1. Traditional Chinese Medicine Hospital of Shunyi District, Beijing 101300, China
  • Received:2013-04-15 Revised:2016-03-09 Online:2013-11-08 Published:2016-03-09

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摘要： 目的 总结质子泵抑制剂不良反应的规律和特点,为临床合理用药提供参考。方法 检索CHKD全文数据库,对2008～2012 年报道的质子泵抑制剂不良反应病例进行统计分析。结果 涉及质子泵抑制剂不良反应的文献30 篇,报道例数34 例；不良反应累及多个系统- 器官,临床症状复杂多样,不良反应症状均比较严重,而且临床上属少见及罕见,经停药处理后预后较好。结论 加强对该类药品不良反应的认识,注意防范,合理选用质子泵抑制剂。

关键词: 质子泵抑制剂, 药品不良反应, 分析

Abstract: Objective To summarize the regularity and characteristics of adverse drug reaction(ADR) induced by proton pump inhibitors, and provide reference for the rational use of drugs in clinic. Methods Related literatures of ADR induced by proton pump inhibitors were collected from CHKD full-text database during 2008～2012, then the included literatures were statistically analyzed. Results A total of 30 literatures relating to ADR induced by proton pump inhibitors were collected, including 34 cases. This group of ADR induced by proton pump inhibitors involved multiple system -organs , the clinical signs were complex and varied, and symptoms of adverse drug reactions were relatively serious, and rare in clinic, but prognosis was good after stopping drug treatment. Conclusion We should strengthen the understanding of these types of adverse drug reactions, pay attention to the prevention and improve the rational use of proton pump inhibitors.

Key words: proton pump inhibitors, adverse drug reaction, analysis

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