二种溶栓剂应用致死亡的病例分析

中国药物警戒 ›› 2010, Vol. 7 ›› Issue (5): 286-289.

二种溶栓剂应用致死亡的病例分析

华潞, 张叶萍, 庞会敏, 胡颖, 李一石^*

中国医学科学院阜外心血管病医院,卫生部心血管药物临床研究重点实验室,北京 100037

收稿日期:2016-02-19 修回日期:2016-02-19 出版日期:2010-05-08 发布日期:2016-02-19
通讯作者: 李一石,女,主任医师,心血管临床药理研究。E-mail:liyishi@public3.bta.net.cn
作者简介:华潞,女,副主任医师,心内科与心血管药物临床评价。
基金资助:
国家“十一五”科技重大专项（2008ZX09312-018）

Analysis of the In-Hospital Mortality Rate of the Patients Using Two Types Thrombolytic Agents

HUA Lu, ZHANG Ye-ping, PANG Hui-min, HU Ying, LI Yi-shi^*

Key Laboratory of Clinical Trial Research in Cardiovascular Drugs, Ministry of Health, Chinese Academy of Medical Science Peking Union Medical College Fu Wai Hospital Beijing 100037,China

Received:2016-02-19 Revised:2016-02-19 Online:2010-05-08 Published:2016-02-19

摘要/Abstract

摘要： 目的分析2005~2009年期间本院应用重组组织型纤溶酶原激活剂（rt-PA）和尿激酶（UK）静脉溶栓治疗患者的院内死亡发生情况。方法对应用rt-PA或UK溶栓治疗的ST段抬高的急性心肌梗死患者（n=57）和肺血栓栓塞症患者（n=60）的溶栓剂应用情况、死亡原因等进行回顾分析研究。结果 117例接受溶栓治疗的患者院内死亡10例（8.5%）,原因为心源性休克（6例）、心脏破裂（3例）和心室颤动（1例）。10例死亡患者中,无1例因出血并发症死亡;7例为ST段抬高的急性心肌梗死患者,肺血栓栓塞症患者因心源性休克死亡3例。应用rt-PA溶栓治疗的98例(84%)患者院内死亡7例,19例患者接受UK溶栓治疗,死亡3例。结论接受溶栓治疗患者的院内死因主要与基础疾病相关,科学规范的应用溶栓治疗是安全的。

关键词: 重组组织型纤溶酶原激活剂, 尿激酶, 院内死亡率

Abstract: Objective To study the in-hospital mortality rate of recombinant human tissue-type plasrninogen activator(rt-PA) and urokinase(UK) from 2005 to 2009. Methods We retrospectively analyzed the type of thrombolytic agents and cause of death in ST elevated acute myocardial infarctiong patients(n=57) and pulmonary thromboembolism pa-tients(n=60). Results In the 117cases, ten patients died in hospital due to cardiac shock(n=6)、cardiac rupture(n=3) and ventricular fibrillation(n=1). No case died of bleeding complication. Seven of ten deaths suffered acute myocardial infarction. The other 3 deathes due to cardiac shock suffered pulmonary thromboembolism. About 84%(98 cases) patients used rt-PA, of whom seven patients died. In the patients using UK(n=19), 3 cases died. Conclusion The in-hospital mortality rate of the patients using thrombolytic therapy was mainly associated with underlying diseases. The scientific and standardized thrombolytic therapy is safe.

Key words: recombinant human tissue-type plasrninogen activator, urokinase, in-hospital mortality rate

中图分类号:

R972.7

华潞, 张叶萍, 庞会敏, 胡颖, 李一石. 二种溶栓剂应用致死亡的病例分析[J]. 中国药物警戒, 2010, 7(5): 286-289.

HUA Lu, ZHANG Ye-ping, PANG Hui-min, HU Ying, LI Yi-shi. Analysis of the In-Hospital Mortality Rate of the Patients Using Two Types Thrombolytic Agents[J]. Chinese Journal of Pharmacovigilance, 2010, 7(5): 286-289.

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