中国药物警戒 ›› 2010, Vol. 7 ›› Issue (5): 265-268.

• 基础研究 • 上一篇    下一篇

牛黄解毒片中砷元素分析

王秀华1, 陈鼎雄2, 李宗3*   

  1. 1福建中医学院药学系,福建 福州 350108;
    2福建省药品检验所,福建 福州350001;
    3福建省药品不良反应监测中心,福建 福州350001
  • 收稿日期:2016-02-19 修回日期:2016-02-19 出版日期:2010-05-08 发布日期:2016-02-19
  • 通讯作者: 李宗,主任药师,药品不良反应监测。 E-mail：lzong2002@yahoo.com.cn
  • 作者简介:王秀华,女,硕士,中药学。

Speciation Analysis of Arsenic in Niuhuang Jiedu Tablets

WANG Xiu-hua1, CHEN Ding-xiong2, LI Zong3,*   

  1. 1Department of Pharmacology, Fujian University of Traditional Chinese Medicine, Fuzhou 350108;
    2Fujian Institute for Drug Control, Fuzhou 350001;
    3Fujian Adverse Drug Reaction Monitoring Center, Fuzhou 350001, China
  • Received:2016-02-19 Revised:2016-02-19 Online:2010-05-08 Published:2016-02-19

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摘要： 目的 对牛黄解毒片中总砷、可溶性砷、可溶性砷（Ⅲ）和砷（Ⅴ）进行分析,为评价牛黄解毒片的安全性提供依据。方法 采用微波消解-原子荧光法测定牛黄解毒片中的总砷含量,50%甲醇浸提-原子荧光法测定可溶性砷,717阴离子交换树脂分离-原子荧光法测定可溶性砷（Ⅲ）和砷（Ⅴ）。结果 3种牛黄解毒片制剂中总砷含量为65.72~75.79 g/kg,可溶性砷占总砷百分比为0.43%~1.23%,其中可溶性砷（Ⅲ）含量0.19~0.55 g/kg,可溶性砷（Ⅴ）含量范围在0.09~0.44 g/kg。结论 不同的牛黄解毒片中可溶性砷及其中两种价态砷的含量差异较大,因此有必要对牛黄解毒片中砷的含量进行质量控制。

关键词: 牛黄解毒片, 砷, 原子荧光

Abstract: Objective The contents of total arsenic、soluble arsenic、 soluble As(Ⅲ) and As(Ⅴ) in Niuhuang Jiedu Tablets were analyzed, in order to evaluate the safety of Niuhuang Jiedu Tablets. Methods Total arsenic in Niuhuang Jiedu Tablets was determined by Atomic fluorescence spectrometry(AFS) with microwave digestion. Soluble arsenic was determined by AFS after 50% Methanol extract treatment. Two kinds of soluble arsenic species As(Ⅲ) and As(Ⅴ) were separated by ion-exchange resin and assayed by AFS. Results The contents of total arsenic in the three Niuhuang Jiedu Tablet products were in the range of 65.72~75.79 g/kg. The percentage of soluble arsenic to total arsenic was between 0.43% ~ 1.23%, in which soluble arsenic(Ⅲ) contents were in the range of 0.19~0.55 g/kg and soluble Arsenic(Ⅴ) contents were in the range of 0.09~0.44 g/kg. Conclusion Soluble Arsenic and its valence in the two kinds of arsenic showed differences in the Niuhuang Jiedu Tablet products. It is necessary to improve quality control of arsenic in Niuhuang Jiedu Tablets.

Key words: Niuhuang Jiedu Tablets, arsenic, Atomic fluorescence spectrometry(AFS)

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