中国药物警戒 ›› 2026, Vol. 23 ›› Issue (7): 727-732.
DOI: 10.19803/j.1672-8629.20260115

• 脓毒症中医药机制与临床用药研究专栏 • 上一篇    下一篇

中药单体及复方调控NF-κB信号通路治疗脓毒症急性肺损伤研究进展

张硕1, 王晶徽1, 周峰1, 白颖璐2,3, 徐霄龙2,3, 陈腾飞2, 刘清泉2,3,*   

  1. 1首都医科大学附属北京中医医院,北京 100010;
    2首都医科大学附属北京中医医院急诊危重症诊疗中心,北京 100010;
    3北京市中医药研究所,北京 100010
  • 收稿日期:2026-02-05 出版日期:2026-07-15 发布日期:2026-07-16
  • 通讯作者: *刘清泉,男,主任医师,教授·博导,中西医结合急诊与危重症。E-mail: liuqingquan2003@126.com
  • 作者简介:张硕,男,在读博士,中医急诊学。
  • 基金资助:
    国家自然科学基金资助项目（82474428）; 国家中医药管理局高水平中医药重点学科建设项目（ZYYZDXK-2023001）

Research progress in the regulation of NF-κB signaling pathway by traditional Chinese medicine monomers and compound formulas in the treatment of sepsis-induced acute lung injury

Zhang Shuo1, Wang Jinghui1, Zhou Feng1, Bai Yinglu2,3, Xu Xiaolong2,3, Chen Tengfei2, Liu Qingquan2,3,*   

  1. 1Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China;
    2Emergency and Critical Care Center, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China;
    3Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China
  • Received:2026-02-05 Online:2026-07-15 Published:2026-07-16

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摘要： 目的 综述中药单体及复方调控核因子κB（Nuclear Factor-Kappa B, NF-κB）信号通路治疗脓毒症急性肺损伤（Sepsis-Acute Lung Injury, SALI）研究现状,为中医药防治SALI提供参考。方法 检索2015—2025年中国知网、PubMed数据库中有关NF-κB、SALI及中药调控机制的文献,观察肺组织病理损伤、湿干比及炎症因子等指标,归纳总结后进行综述分析。结果 NF-κB作为关键炎症调控通路,其异常激活与SALI发生发展密切相关。黄芩苷、黄芪甲苷、清瘟败毒饮等中药单体及复方可通过调控NF-κB信号通路,减少促炎因子释放、缓解氧化应激、调节细胞凋亡及自噬,减轻SALI。目前研究存在机制挖掘不深、模型与临床差距大、多组学技术应用不足及临床转化不足等问题。结论 中药单体及复方通过调控NF-κB信号通路对SALI具有明确保护作用,但需加强多通路交叉研究、优化模型构建、推进多组学整合与规范临床研究设计,以实现中医药治疗SALI基础与临床双向转化。

关键词: 脓毒症急性肺损伤, 核因子κB, 黄芩苷, 黄芪甲苷, 清瘟败毒饮

Abstract: Objective To review the latest research findings on the regulation of the nuclear factor-kappa B (NF-κB) signaling pathway by traditional Chinese medicine (TCM) monomers and compound formulas in the treatment of sepsis induced acute lung injury (SALI), and to provide a reference for the prevention and treatment of SALI with TCM. Methods Literature on NF-κB, SALI, and the regulatory mechanisms of TCM that was published in 2015-2025 was retrieved from CNKI and PubMed databases. Such indicators as pathological damage to lung tissue, the wet-to-dry ratio, and inflammatory factors were observed before the data was analyzed. Results As a key inflammatory regulatory pathway, NF-κB was closely associated with the onset and progression of SALI when aberrantly activated. TCM monomers (such as baicalin and astragaloside Ⅳ) and compound formulas (such as Qingwen Baidu decoction) could reduce the release of pro-inflammatory cytokines, alleviate oxidative stress, regulate apoptosis and autophagy, and ameliorate SALI by regulating the NF-κB signaling pathway. However, current research was still facing such challenges as the lack of investigations into the mechanisms, large gaps between animal models and clinical applications, limited applicability of multi-omics technologies, and inadequate clinical translation. Conclusion TCM monomers and compound formulas have protective effects against SALI by regulating the NF-κB signaling pathway. However, more efforts should be devoted to studies on cross-talk between multiple pathways, optimization of modeling, promotion of multi-omics integration, and standardization of clinical research design in order to accelerate bidirectional bench-to-bedside translation of TCM in the treatment of SALI.

Key words: Sepsis-Induced Acute Lung Injury, NF-κB, Baicalin, Astragaloside Ⅳ, Qingwen Baidu Decoction

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