中国药物警戒 ›› 2026, Vol. 23 ›› Issue (3): 280-284.
DOI: 10.19803/j.1672-8629.20250555

• 基础与临床研究 • 上一篇    下一篇

蕲艾中重金属元素暴露水平及综合风险评估

费毅琴, 肖凌, 吕盼, 汪波*, 聂晶#   

  1. 湖北省药品监督检验研究院（湖北生物制品检定所）,国家药品监督管理局中药质量控制重点实验室,湖北省药品质量检测与控制工程技术研究中心,湖北 武汉 430075
  • 收稿日期:2025-08-15 出版日期:2026-03-15 发布日期:2026-03-17
  • 通讯作者: *汪波,男,副研究员,中药检验与质量控制技术研究。E-mail: wangbo@hubyjs.org.cn。#为共同通信作者。
  • 作者简介:费毅琴,女,本科,高级工程师,中药检验与质量标准研究。
  • 基金资助:
    湖北省自然科学基金资助项目（2025AFD714）; 湖北省药品安全监管科研项目（20250101）

Exposure Levels of Heavy Metals in Artemisia argyi and Risk Assessment

FEI Yiqin, XIAO Ling, LYU Pan, WANG Bo*, NIE Jing#   

  1. Hubei Institute for Drug Control, Hubei Institute for Biological Products Inspection, NMPA Key Laboratory of Quality Control of Chinese Medicine, Hubei Engineering Research Center for Drug Quality Control, Wuhan Hubei 430075, China
  • Received:2025-08-15 Online:2026-03-15 Published:2026-03-17

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摘要： 目的 通过对26批蕲艾中10种重金属元素综合风险评估,为精准识别蕲艾风险提供参考。方法 采用电感耦合等离子体质谱法（ICP-MS）测定26批蕲艾中铅（Pb）、镉（Cd）、砷（As）、汞（Hg）、铜（Cu）、铝（Al）、锰（Mn）、镍（Ni）、铬（Cr）、锌（Zn）残留量。采用口服摄入风险评估、非致癌风险评估和致癌风险评估3种方法分析蕲艾中重金属有害元素污染的健康风险。结果 蕲艾中元素含量均值为：Al、Mn>Zn>Cu>Ni、Pb>Cr、Cd>As>Hg。26批样品Pb、Cd、As、Hg、Cu元素含量均低于植物类药材及饮片一致性限量指导值。口服摄入风险：每日因食用蕲艾造成的重金属摄入量（EDI）均小于每日可接受摄入量（PTDI）,口服摄入风险可接受。非致癌风险：样品的非致癌危害指数（HI）均小于1,整体风险较低;其中Mn非致癌风险最高,其次是As和Cd。致癌风险：Pb致癌风险较低,Cd和As暴露可能存在一定致癌风险,需被关注。结论 本研究建立的综合风险评估方法,整合多维度风险指标,精准识别并量化影响蕲艾安全风险的关键因素,为蕲艾产业的可持续发展提供参考。

关键词: 蕲艾, 有害元素, 暴露水平, 口服摄入风险, 非致癌风险, 致癌风险

Abstract: Objective To conduct a comprehensive risk assessment of ten heavy metal contaminants in 26 batches of Artemisia argyi in order to establish a reference framework for precise evaluation of associated health risks. Methods The concentrations of Pb, Cd, As, Hg, Cu, Al, Mn, Ni, Cr, and Zn in Artemisia argyi samples were quantified using inductively coupled plasma mass spectrometry (ICP-MS). The health risks of heavy metal contamination were analyzed using three methods: oral intake risk assessment, non-carcinogenic risk assessment and carcinogenic risk assessment. Results The mean elemental concentrations were the highest with Al, followed by Mn, Zn, Cu, Ni, Pb, Cr, Cd, As and Hg. The levels of Pb, Cd, As, Hg, and Cu in each batch were below the established safety thresholds for medicinal plants and decoction pieces. Oral intake risk assessment indicated that the estimated daily intake (EDI) of heavy metals from Artemisia argyi consumption remained within provisional tolerable daily intake (PTDI) limits, suggesting a negligible risk. For non-carcinogenic risks, the hazard index (HI) across samples was<1, indicating a negligible overall risk, with Mn posing the highest non-carcinogenic risk, followed by As and Cd. Carcinogenic risk evaluation identified Cd and As as contributors to measurable carcinogenic potential and worthy of attention, whereas Pb posed a minimal carcinogenic risk. Conclusion The risk assessment method established in this study integrates multi-dimensional risk indicators, enabling precise identification and quantification of key determinants of safety risks of Artemisia argyi. This study is expected to provide a reference for the sustainable development of the Artemisia argyi industry.

Key words: Artemisia argyi, Harmful Elements, Exposure Level, Oral Intake Risk, Non-Carcinogenic Risk, Carcinogenic Risk

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