中国药物警戒 ›› 2025, Vol. 22 ›› Issue (2): 183-187.
DOI: 10.19803/j.1672-8629.20240212

• 中药/中成药减毒增效相关循证评价研究专栏 • 上一篇    下一篇

溃疡性结肠炎患者对于中成药等中医药疗法接受度的多中心横断面研究

卜志军1, 刘芳2, 侯文斌1, 苏娟萍3, 刘艳迪4, 苏晓兰5, 王建云6, 李军祥7, 孙屿昕1, 陈韵如1, 郑酉友1, 王雪惠1, 刘冯双8, 田园春9, 刘建平1, 刘兆兰1,*   

  1. 1北京中医药大学循证医学中心,北京 100029;
    2中日友好医院消化科,北京 100029;
    3山西省中医院脾胃病科,山西 太原 030012;
    4天津市人民医院消化科,天津 300122;
    5中国中医科学院望京医院脾胃病科,北京 100102;
    6北京中医药大学第三附属医院脾胃病科,北京 100078;
    7北京中医药大学东方医院脾胃肝胆科,北京,100078;
    8湖北中医药大学针灸骨伤学院,湖北 武汉 430065;
    9湖北中医药大学中医学院,湖北 武汉 430065
  • 收稿日期:2024-03-30 出版日期:2025-02-17 发布日期:2025-02-17
  • 通讯作者: *刘兆兰,女,博士,教授,中医药循证评价方法学。E-mail：lzl1019@163.com
  • 作者简介:卜志军,男,硕士,中医药循证评价方法学。
  • 基金资助:
    国家自然科学基金资助项目（82374298）; 北京中医药大学学科后备带头人支持计划（90010960920033）

Acceptance of Traditional Chinese Medicines in Patients with Ulcerative Colitis: a Multicenter Cross-Sectional Study

BU Zhijun1, LIU Fang2, HOU Wenbin1, SU Juanping3, LIU Yandi4, SU Xiaolan5, WANG Jianyun6, LI Junxiang7, SUN Yuxin1, CHEN Yunru1, ZHENG Youyou1, WANG Xuehui1, LIU Fengshuang8, TIAN Yuanchun9, LIU Jianping1, LIU Zhaolan1,*   

  1. 1Center for Evidence-Based Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;
    2Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China;
    3Department of Spleen and Gastroenterology, Shanxi Provincial Hospital of Traditional Chinese Medicine, Taiyuan Shanxi 030012, China;
    4Department of Gastroenterology, Tianjin People's Hospital, Tianjin 300122, China;
    5Department of Spleen and Stomach Diseases, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China;
    6Department of Spleen and Stomach Diseases, the Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100078, China;
    7Department of Spleen, Stomach and Hepatobiliary, East Hospital, Beijing University of Chinese Medicine, Beijing 100078, China;
    8College of Acupuncture, Moxibustion and Orthopedics, Hubei University of Chinese Medicine, Wuhan Hubei 430065, China;
    9College of Traditional Chinese Medicine, Hubei University of Chinese Medicine, Wuhan Hubei 430065, China
  • Received:2024-03-30 Online:2025-02-17 Published:2025-02-17

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摘要： 目的 调研溃疡性结肠炎（UC）门诊患者对于中医药治疗的接受度,分析患者接受或不接受中医药治疗的主要原因。方法 调研北京地区部分医院门诊就诊的UC患者,使用SPSS 26.0进行统计描述和Logistic回归分析。结果 共收集问卷236份,有效问卷208份。中位年龄40（32, 50）岁, 男性123人（59.13%）,女性85人（40.87%）。根据多因素Logistic回归分析显示,性别（OR=2.53,95%CI：1.07~6.01）、既往使用过五味苦参肠溶胶囊（OR=5.08,95%CI：1.05~24.67）以及在过去的2周内,UC患者有1 d或某几天忘记服用药物（OR=0.27,95%CI：0.09~0.82）与是否选择中医药治疗UC存在一定的相关性（P<0.05）。针对患者是否愿意接受中医药治疗的原因进行了问卷分析,结果显示,在175例愿意接受中医药治疗的患者中,绝大多数选择接受的主要原因是中医药的不良反应较小;而在33例拒绝中医药治疗的患者中,主要原因是认为中医药无法预防或治疗 UC。结论 性别、既往用药经历是影响UC患者对中医药治疗接受度的关键因素。此外,药物依从性和中医药价格的合理性也是UC临床实践中需关注的重点。

关键词: 溃疡性结肠炎, 五味苦参肠溶胶囊, 中医药价格, 服药依从性, 中医药治疗接受度, 多因素Logistic回归分析

Abstract: Objective To assess the level of acceptance of traditional Chinese medicine (TCM) among outpatients with ulcerative colitis (UC) and to find out what shapes their decision to accept or decline TCM treatment. Methods A survey was conducted among UC outpatients at various hospitals in Beijing. The collected data was analyzed using Statistical Package for the Social Sciences (SPSS) version 26.0. Results The survey yielded 236 questionnaires, with 208 valid responses. The median age of the participants was 40 years (interquartile range: 32, 50), comprising 123 males (59.13%) and 85 females (40.87%). Multivariable logistic regression revealed that gender [Odds Ratio (OR)=2.53, 95%CI: 1.07~6.01], prior use of Wuweikushen capsules (OR=5.08, 95%CI: 1.05~24.67), and the lack of compliance within the past two weeks (OR=0.27, 95%CI: 0.09~0.82) were significantly correlated with the acceptance of TCM for UC treatment (P<0.05). Among the participants, A questionnaire analysis was conducted to examine the reasons why patients were willing or unwilling to accept TCM treatment. The results showed that among the 175 patients who were willing to receive TCM treatment, the majority chose it primarily because of its fewer adverse effects. In contrast, among the 33 patients. Conclusion Gender and past medication experiences make a huge difference to the acceptance of TCM treatments among UC patients. In addition, medication compliance and the affordability of TCM are also focuses of attention in clinical practice.

Key words: Ulcerative Colitis, Wuweikushen Capsules, Price of TCM, Medication Compliance, Acceptance of TCM, Multi-variable Logistic Regression Analysis

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